2-Iodophenylboronic acid

As compounds exhibiting enhancing effects on CL reactions, a variety of phenols, e.g., firefly luciferin and 6-hydroxybenzothiazole derivatives [12,13], 4-iodophe-nol [14], 4-(4-hydroxyphenyl)thiazole [15], 2-(4,-hydroxy-3 -methoxy-benzyli-dene)-4-cyclopentene-l,3-dione (KIH-201) [16], and 2-(4-hydroxyphenyl)-4,5-diphenylimidazole (HDI) and 2-(4-hydroxyphenyl)-4,5-di(2-pyridyl)imidazole (HPI)[17] (Fig. 6A), and phenylboronic acid derivatives, e.g., 4-phenylylboronic acid [18], 4-iodophenylboronic acid [19], and4-[4,5-di(2-pyridyl)-l //-imidazol-2-yl]phenylboronic acid (DPPA) [20] (Fig. 6B), in the luminol/hydrogen peroxide/peroxidase system are well known. Rhodamine B and quinine are used as sensitizers in the CL-emitting reaction between cerium (IV) and thiol compounds. This CL reaction was successfully applied to the sensitive determination of various thiol drugs [21-32],... 

The enhancer SPTZ was synthesized in high yield and extreme purity, using a new one-pot procedure from phenothiazine and 1,3-propanesultone. Its performance and that of other commonly used enhancers, p-coumaric acid, p- iodophenylboron ic acid and /5-iodophenol was evaluated under similar conditions. The best performance, both in terms of luminosity and duration was obtained with SPTZ. In the next experiment, 4-dimethylaminopyridine (DMAP), a powerful acylation catalyst, was added to each substrate solution. While a very slight signal increase was observed for p-iodophenol and 4-iodophenylboronic acid (about 10%), the effect was much more significant for SPTZ (>800%). Therefore, all further studies were focused on the SPTZ system. 

A series of heterocyclic compounds containing trivalent iodine, oxygen and boron in a five-membered ring has been prepared by oxidative cyclization of commercially available orf/to-iodophenylboronic acids 182 and 185... 

Several heterocyclic compounds containing trivalent iodine, oxygen, and boron in a five-membered ring have been prepared by oxidative cyclization of the orifco-iodophenylboronic acids 168 and 171 (201IICI1263). 1-Chloro-4-fluoro-lH-lX -benzo[(/][l,2,3]iodoxaborol-3-ol 170 was formed in the reaction of 2-fluoro-6-iodophenylboronic acid 168 with chlorine followed by treatment of the intermediate iododichloride 169 with water. The... 

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