3.6- Pyridinedicarboxylic acid

At the beginning, we used NA as the inducer to the culture medium. However, the activity was not induced to achieve a high level production of 6-CHP. So we screened various nicotinic acid analogues such as 6-chloronicotinic acid, 6-fluoronicotinic acid, 2-chloronicotinic acid, 2-hydroxynicotinic acid, 2,6-dihydroxypyridine, 2,3-pyridinedicarboxylic acid, 3,4-pyridinedicarboxylic acid,... 

Pyridine-3,5-dicarboxylic acid, 2,6-dimethyl-synthesis, 2, 457 Pyridinedicarboxylic acids synthesis... 

The procedure for preparing 6-hydroxynicotinic acid is also based on a method described by von Pechmann. 6-Hydroxynico-tinic acid has also been prepared by decarboxylation of 6-hy-droxy-2,3-pyridinedicarboxylic acid by heating 6-hydra-zinonicotinic acid or its hydrazide with hydrochloric acid by the action of carbon dioxide on the sodium salt of a-pyridone at 180-200 and 20 atmospheres by heating the nitrile of 6-chlo-ronicotinic acid with alcoholic sodium hydroxide or hydrochloric acid from 6-aminonicotinic acid and by the prolonged action of concentrated ammonium hydroxide on methyl cou-malate. ... 

The present method for preparing aromatic dicarboxylic acids has been used to convert phthalic or isophthalic acid to tereph-thalic acid (90-95%) 2,2 -biphenyldicarboxylic acid to 4,4 -biphenyldicarboxylic acid 3,4-pyrroledicarboxylic acid to 2,5-pyr-roledicarboxylic acid and 2,3-pyridinedicarboxylic acid to 2,5-pyridinedicarboxylic acid. A closely related method for preparing aromatic dicarboxylic acids is the thermal disproportionation of the potassium salt of an aromatic monocarboxylic acid to an equimolar mixture of the corresponding aromatic hydrocarbon and the dipotassium salt of an aromatic dicarboxylic acid. The disproportionation method has been used to convert benzoic acid to terephthalic acid (90-95%) pyridine-carboxylic acids to 2,5-pyridinedicarboxylic acid (30-50%) 2-furoic acid to 2,5-furandicarboxylic acid 2-thiophenecar-boxylic acid to 2,5-thiophenedicarboxylic acid and 2-quinoline-carboxylic acid to 2,4-quinolinedicarboxylic acid. One or the other of these two methods is often the best way to make otherwise inaccessible aromatic dicarboxylic acids. The two methods were recently reviewed. ... 

Chemical Name 1,4-dihydro-2,6-dimethyl-4-(2 -nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl eater... 

When reacted with tetraalkylammonium halides, hydrated [Me2Sn(IV)], [Bu2Sn(IV)]2-",2 [Ph2Sn(IV)]2-", 5 and [EtPhSn(lV)]2-",2 ester derivatives of 2,6-pyridinedicarboxylic acid yield tetraalkylammonium diorganohalogeno(2,6-pyr-idinedicarboxylato)stannates. Both classes of compounds exhibit high in vitro antitumor activity. 

CN 2-l(2-ammoethoxy)methyl]-4-(2-chlorophenyl)-l.4-dihydro-6-rtiethyl-3,5-pyridinedicarboxylic acid 3-cthyl 5-methyl e.ster... 

CN [S-(R, R )]-l,4-Dihydro-2,6-dimethyl-4-(3-nilrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-(phenyimethyl)-3-pyrrolidinyl ester hydrochloride... 

CN 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester... 

Potassium hydrogen tartrate, 1462 /s-Propcnc-l,2,3-tricarboxylic acid, 2342 Propiolic acid, 1086 2,5-Pyridinedicarboxylic acid, 2696 Pyruvic acid, 1150... 

A review by Galli et al. describes several buffer-absorbing chromophores as co-ions. These include phthalate, PDG (2,6-pyridinedicarboxylic acid), PMA (1,2,4,5-benzenetetra-carboxylic acid or pyromellitic acid), TMA (trimellitic acid), MES, 2,4-dihydrobenzoic acid with s-aminocaproic acid, p-hydroxybenzoate, p-anisate, 3,5-dinitrobenzoic acid, salicylic acid with TRIS, benzoic acid with tris (hydroxymethyl)aminomethane (TRIS), and many others. On the other hand, some inorganic chromophores such as chromate (Figure 9) or molybdate may be added to a buffer. A BGE-containing chromate should have a pH above 8, because it precipitates below this value. The advantage of a TRIS buffer or buffers at around pH 6 is that carbonate will not interfere with the separation because it is not soluble in TRIS or at lower pHs. 

Figure 10.5. Adsorbate molecular orientation at the electrode surface d) nicotinic acid (Z ) benzoic acid (c) 2,6-pyridinedicarboxylic acid. (From Ref. 12, with permission from the American Chemical Society.)...

Pyridinedicarboxylic acid, 2696 Rhenium chloride trioxide, 4045 Rhenium hexamethoxide, 2603 Rhenium nitride tetrafluoride, 4344 Selenium dioxide, 4838... 

The structure of quinolinic acid (2,3-pyridinedicarboxylic acid, C5H3N(COOH)2) has been determined by neutron diffraction at four temperatures 298, 100, 80, and... 

Pyridinedicarboxylic acid (dipicolinic acid) is a widely used building block in coordination and supramolecular chemistry. The crystal stractrrre of dipicolinic acid was first solved in 1973, which confirmed its molectrlar formtrla of C7H5NO4, a molar mass of 167.119 g mol , and the resrrlting composition of its constituent atoms (C, 50.31% H, 3.02% N,... 

Hydroxymethylpyridines are reduced directly to alkylpyridines in the presence of samarium diiodide <99TL8823>. The electroreduction of pyridinedicarboxylic acid derivatives to 1 -and 1,4-dihydropyridines has been achieved in good yield <99TL8587>. 

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