3.5- Pyridinedicarboxylic acid, 2,6-dimethyl

Chemical Name 1,4-dihydro-2,6-dimethyl-4-(2 -nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl eater... [Pg.1076]

FP Guengerich. Low isotope effects in the hydrogenation of l,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P450 enzymes are consistent with an electron/pro-ton/electron transfer mechanism. Chem Res Toxicol 3 21—26, 1990. [Pg.354]

Pyridine-3,5-dicarboxylic acid, 2,6-dimethyl-synthesis, 2, 457 Pyridinedicarboxylic acids synthesis... [Pg.789]

CN [S-(R, R )]-l,4-Dihydro-2,6-dimethyl-4-(3-nilrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-(phenyimethyl)-3-pyrrolidinyl ester hydrochloride... [Pg.180]

CN 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester... [Pg.834]

N1 - 3 5-PYRIDINEDICARBOXYLIC ACID 1 6-DIHYDRO-2 >6-0IMETHYL-6-C 2-NITROPHENYD- DIMETHYL ESTER... [Pg.185]

Chemical Name 3,5-Pyridinedicarboxylic acid, l,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester... [Pg.2449]

Cyclization of a 4-(3-thienyl)-3,5-pyridinedicarboxylic acids in hot H2S04 was shown to be a viable route to the substituted 8-oxo-6-aza-8//-indeno[2,1-6] thiophenes (e.g. (28)) (Equation (8)) <87H(26)1535>. In the case of the dimethylated carboxylic acid shown, the neutral tricyclic heterocycle (28) is obtained in 21% yield. [Pg.885]

SYNS BAY 1518 (2,4 -BIPYRIDINE)-3, 5 -DICARBOXYLIC ACID, l ,4 -DIHYDRO-2, 6 -DIMETHYL-,-DIETHYL ESTER ISOCINCHOMERONIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-PYRIDYL)-, DIETHYL ESTER 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-PYRIDYL)-, DIETHYL ESTER... [Pg.487]

SYNS (S)-(-l-)-AE 0047 (S)-AE0047 B 859-35 B 8509-035 BY 935 DEXNIGULDIPINE HYDROCHLORIDE (R)-NIGALDIPINE HYDROCHLORIDE 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-(4-(4-piPHENYL-METHYL)-1-PIPERAZINYL)PHENYL)ETHYL METHYL ESTER, DIHYDROCHLORIDE, (S)-(+)- (S)-(+)-WATANI-DIPINE HYDROCHLORIDE WATANTDIPINE HYDROCHLORIDE (S)-ENANTIOMER... [Pg.998]

The presence of a piperidine ring in these alkaloids was demonstrated by successive dehydrogenation, permanganate oxidation, and methylation of lythranine (18 R1 = R3 = H, R2 = Ac) to yield the dimethyl ester of 2,6-pyridinedicarboxylic acid.23 Treatment of O-methyl-lythranidine with ethyl... [Pg.37]

Nisoldipine. l,4-Dihydro-2,6-dimethyl-A.(2-ni. tmphenyl)-3,S-pyridinedicarboxylic acid methyl 2-methyl-propyl ester isobutyl methyl l,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate isobutyl 1,4-dihy-dto -5 -methox year bony] -2.6 -dimethyl -4 -(2 -nitroplienyl) -3 pyridinecar boxy late 2,6-dimethyl-3-car bomethoxy-4-(2-nitrOphenyl)-5 -carbisobutoxy 1,4-dihydropyridine Bay k 5552 Baymycard Syscor. C. HaNjO. mol wt 388.42. C 61.85%. H 6.23%. N 7.21%, O 24.71%. Dihydro pyridine calcium channel blocker. Prepn E. Wehinger et ah, Ger. pat. 2,549,568 eidem. U.S. pat. 4,154,839 (1977. 1979 both to Bayer). Pharmacology S. Kazda et ah, Arzneimittel-Forsch. 30, 2144 (1980). Preferential effect on vascular smooth muscle in humans A. Vogt el ah. ibid. 2162. [Pg.1038]

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