Pyridinedicarboxyl

The 3,4-pyridinedicarboxylic phenylhydrazide (337), however, did cyclize in one of the earliest pyrido[3,4-higher temperature (12M(33)393, 66CPBIOIO). 

Pyridine-3,5-dicarboxylic acid, 2,6-dimethyl-synthesis, 2, 457 Pyridinedicarboxylic acids synthesis... 

The procedure for preparing 6-hydroxynicotinic acid is also based on a method described by von Pechmann. 6-Hydroxynico-tinic acid has also been prepared by decarboxylation of 6-hy-droxy-2,3-pyridinedicarboxylic acid by heating 6-hydra-zinonicotinic acid or its hydrazide with hydrochloric acid by the action of carbon dioxide on the sodium salt of a-pyridone at 180-200 and 20 atmospheres by heating the nitrile of 6-chlo-ronicotinic acid with alcoholic sodium hydroxide or hydrochloric acid from 6-aminonicotinic acid and by the prolonged action of concentrated ammonium hydroxide on methyl cou-malate. ... 

The present method for preparing aromatic dicarboxylic acids has been used to convert phthalic or isophthalic acid to tereph-thalic acid (90-95%) 2,2 -biphenyldicarboxylic acid to 4,4 -biphenyldicarboxylic acid 3,4-pyrroledicarboxylic acid to 2,5-pyr-roledicarboxylic acid and 2,3-pyridinedicarboxylic acid to 2,5-pyridinedicarboxylic acid. A closely related method for preparing aromatic dicarboxylic acids is the thermal disproportionation of the potassium salt of an aromatic monocarboxylic acid to an equimolar mixture of the corresponding aromatic hydrocarbon and the dipotassium salt of an aromatic dicarboxylic acid. The disproportionation method has been used to convert benzoic acid to terephthalic acid (90-95%) pyridine-carboxylic acids to 2,5-pyridinedicarboxylic acid (30-50%) 2-furoic acid to 2,5-furandicarboxylic acid 2-thiophenecar-boxylic acid to 2,5-thiophenedicarboxylic acid and 2-quinoline-carboxylic acid to 2,4-quinolinedicarboxylic acid. One or the other of these two methods is often the best way to make otherwise inaccessible aromatic dicarboxylic acids. The two methods were recently reviewed. ... 

Chemical Name 1,4-dihydro-2,6-dimethyl-4-(2 -nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl eater... 

When reacted with tetraalkylammonium halides, hydrated [Me2Sn(IV)], [Bu2Sn(IV)]2-",2 [Ph2Sn(IV)]2-", 5 and [EtPhSn(lV)]2-",2 ester derivatives of 2,6-pyridinedicarboxylic acid yield tetraalkylammonium diorganohalogeno(2,6-pyr-idinedicarboxylato)stannates. Both classes of compounds exhibit high in vitro antitumor activity. 

CN 2-l(2-ammoethoxy)methyl]-4-(2-chlorophenyl)-l.4-dihydro-6-rtiethyl-3,5-pyridinedicarboxylic acid 3-cthyl 5-methyl e.ster... 

CN [S-(R, R )]-l,4-Dihydro-2,6-dimethyl-4-(3-nilrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-(phenyimethyl)-3-pyrrolidinyl ester hydrochloride... 

CN 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester... 

Other decarboxylations reported by Takahashi have proved irrep-roducible. The reaction between 2,2 -biphenyldicarboxylic acid anhydride in alkali and mercuric oxide in acetic acid was claimed to give 2 -mercurio-2-biphenylcarboxylate by hemidecarboxylation [Eq. (84)] (97) but yielded instead mercuric 2,2 -biphenyldicarboxylate and negligible decarboxylation [Eq. (85)] (98). Similarly, the reaction between sodium 2,3-pyridinedicarboxylate and mercuric oxide in acetic acid, reported to give... 

Jakubiak, A. Szymanowski, J. Cote, G. Extraction of copper(II) from chloride solutions by pyridinedicarboxylates. 

Potassium hydrogen tartrate, 1462 /s-Propcnc-l,2,3-tricarboxylic acid, 2342 Propiolic acid, 1086 2,5-Pyridinedicarboxylic acid, 2696 Pyruvic acid, 1150... 

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