Pyridine-2-aldoxime methiodide 2-PAM

In 1955, Wilson and Ginsburg in the United States and Childs et al. in the United Kingdom researched and published independently on the efficacy of the compound 2-pyridine aldoxime methiodide (2-PAM) as a reactivator of phospho-rylated cholinesterases. The next compound of interest was trimedoxime, which was synthesized... 

Jager BV and Stagg GN (1958). Toxicity of diacetyl-monoxime and of pyridine-2-aldoxime methiodide in man 15-30 mg/kg 2-PAM no effects on EEG in a healthy man. Bull Johns Hopkins Hosp, 102, 203-211. 

Its excellent pesticidal properties are vitiated by its high toxicity to mammals. Its acute oral lDj, for rats is S.4 mg/kg. In chronic oral toxicity tests the no lTect level for rats was found to be SO ppm. Atropine sulfate appeared to be an antidote of oxamil, but pyridine-2-aldoxime methiodide (PAM), a well-known antidote to cholinesterase inhibitors, does not appear to be effective in this respect. 

Loomis, T. A. (1963). Distribution and excretion of pyridine-2-aldoxime methiodide (PAM) Atropine and PAM in sarin poisoning. To.xicot. Appl. Pharmacol. 5,489—499. 

Funckes AJ. Treatment of severe parathion poisoning with 2-pyridine aldoxime methiodide (2-PAM). Arch Environ Health. 1960 1 404-406. 

Jager BV, Stagg GN, Green N, Jager L. Studies on distribution and disappearance of pyridine-2-aldoxime methiodide (PAM) and of diacetyl monoxime (DAM) in man and in experimental animals. Bull Johns Hopkins Hosp. 1958 102 225-234. 

Treatment for Parathion poisoning has been improved by the availability of the oxime 2-PAM (2-pyridine aldoxime methiodide) (ref. 

Synonyms. PAM P-2-AM 2-PAM Iodide 2-PAMI Pamium Pyraloxime Iodide 2-Pyridine Aldoxime Methiodide. 

Quinby GE, Loomis TA, Brown HW. Oral occupational parathion poisoning treated with 2-PAM iodide (2-pyridine aldoxime methiodide). N Engl J Med. 1963 268 639-643. 

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