Sarin poisoning

Cholinesterase inhibition causing widespread neurologic deficits, esp muscle and CNS function 

vision - blurred Eyes, vision - dim Eyes - pain [2] 

Mentation, judgement - impaired [5] Mentation, memory - impaired (amnesia) [5] Mentation - confusion [5] 

Muscles, movements local - fasciculations Muscles - paralysis [3] 

drainage - increased (rhinorrhea, coryza) Nose - congested Seizures [1] 

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Studies on a group of oximes as therapeutic compounds In sarin poisoning. J. Pharmacol. Exp. Therap. 119 522-531. 

M. Nagao, T. Takatori, Y. Matsuda, M. Nakajima, H. Iwase and K. Iwadate, Definitive evidence for the acute sarin poisoning diagnosis in the Tokyo Subway, Toxicol. Appl. Pharmacol., 144, 198-203 (1997). 

Fidder and coworkers (50) developed a versatile procedure that identifies phosphylated butyrylcholi-nesterase. Adducted butyrylcholinesterase is isolated from plasma by affinity chromatography (procainamide column), digested with pepsin, and a nonapep-tide containing the phosphylated active-site serine residue detected using LC/ESI/MS/MS (quadrupole-TOF hybrid instrument). A C18 150 x 0.3-mm LC column was used, eluted with a gradient of water-acetonitrile-0.2 % formic acid. The method was applied successfully to casualties of sarin poisoning from the Tokyo subway attack (see Chapter 17). 

Nakajima, T., Ohta, S., Morita, H., Midorikawa, Y., Mimura, S., Yanagisawa, N. (1998). Epidemiological study of sarin poisoning in Matsumoto City, Japan. Journal of Epidemiology, 8(1), 33-41. 

Morita, H., N. Yanagisawa, T. Nakajima, M. Shimizu, H. Hirabayashi, H. Okudera, M. Nohara, Y. Midorikawa, and S. Mimura. 1995. Sarin poisoning in Matsumoto, Japan. Lancet 346 (8970) 290-293. 

Murata, K., S. Araki, K. Yokoyama, T. Okumura, S. Ishimatsu, N. Takasu, and R.F. White. 1997. Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack. J. Neurol. 244 601-606. 

Nakajima, T., S. Sato, H. Morita, and N. Yanagisawa. 1997. Sarin poisoning of a rescue team in the Matsumoto sarin incident in Japan. Occup. Environ. Med. 54 697-701. 

Yokoyama, K., Araki, S., Murata, K., Nishikitami, M., Okomura, T., Ishimatsu, S., Takasu, M. (1998). Chronic neurobehavioral and central autonomic nervous system effects in Tokyo subway sarin poisoning. J. Physiol. 92 317-23. 

Yoshida, T. (1994). Toxicological reconsideration of organophosphate poisoning in relation to the possible nerve-gas sarin-poison disaster happened in Matsumoto-city, Nagano. Jpn. J. Toxicol. Environ. Health 40 486-97. 

Hatta, K., Miura, Y., Asukai, N., Hamahe, Y. (1996). Amnesia Ifom sarin poisoning. Lancet 347 1343. 

Ohtomi, S., Takase, M., Kumagai, F. (1996). Sarin poisoning in Japan. A clinical experience in Japan Self Defense Force (JSDF) Central Hospital. Int. Rev. Arm. For. Med. Ser. 69 97. 

Masuda, N., Takatsu, M., Morinari, H. (1995). Sarin poisoning in Tokyo subway. Lancet 345 1446-7. 

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