Pyretic

The tetralins 18a and 18b were potent serotonin agonists in dog vascular smooth muscle (33) but did not elicit hallucinogen-like action in a conditioned avoidance response model in rats (156). However, 18b is a potent pyretic agent in rabbits and produces a rage response in cats (166). Addition of a double bond into the 3,4-position of the tetralins led to decreased serotonin-like action... 

Bulatovic, S.M., Evaluation of New HD Collectors in Flotation of Pyretic Copper-Gold Ores from B.C. Canada, Internal R D Report LR029, 1993. 

Paracetamol is indicated as an anti-pyretic and may be safely administered in a patient on warfarin. A topical nasal decongestant is effective for rhinorrhoea (runny nose) and would not interfere with warfarin. Altering the dose of warfarin is only recommended on the basis of results of international normalised ratio (INR) levels. 

Rimcazole (BW 234U) (496) is a novel anti-pyretic, neuroleptic agent. It was found to be a specific competitive antagonist of a-sites in the brain. It reverses psychotic conditions induced in humans by phencyclidine and/or a-opiod antagonists, probably by binding to receptors in the brain (459-461). Rimcazole has an indirect effect on dopamine neurons with relative selectivity for AlO dopamine cells (462). 

Pyretic activity. Fruit juice, administered intravenously to guinea pigs at a dose of 10 mL/kg four times at 1-hour intervals, was active ... 

Acetylsalicyclic acid, aspirin, inhibits the cyclooxygenase-catalyzed first step in the biosynthesis of prostaglandins, prostacyclins and thromboxanes. These latter substances are responsible for the inflammatory and pyretic effects of infection. It is believed that the chemical inhibition reaction involves the acetylation of the enzyme by the aspirin. 

Indomethacin is a non-steroidal, anti-inflammatory agent with anti-pyretic and analgesic properties discovered and developed by the Merck Sharp and Dohme Research Laboratories(1). 

DNA ligand (alA-R, (a2A-R, AChE, ATPase, BChE, CDPK, ChAT, diamine oxidase, DNA, 5HT2-R, mACh-R, nACh-R, MLCK, PKA, PKC, RT) [antibacterial, antimalarial, anti-pyretic, bitter stomachic, cytotoxic]... 

The syntheses of phenothrin analogues of lower insecticidal activity and of other chrysanthemate esters have been reported. Further pyrethroid papers concern the relationship between insecticidal toxicity and cyclopropane substituents in pyret-hroids, the photochemistry of the most potent known pyrethroid,and the metabolism of permethrin in rats (c/. Vol. 6, p. 13). " ... 

According to Ramadan and cowoikers (36), aqueous extract of the baobab fruit pulp produces a marked anti-inflammation activity. The effect was comparable to that induced by standard phenylbutazone (15 mg/kg). This antiinflammatory effect may be due to the presence of sterols, saponins and triterpenes in the aqueous extract. The extract also shows a marked antipyretic activity (36). The antipyretic activity of the extract resembles that normally induced by standard dose of administered acetylsalicyhc acid (ASA) in hyperthermic rats. Leaves are applied locally for a variety of inflammatoiy conditions, insect bites and guinea worm sores (8). Anti-pyretic activity has been reported (36). 

The cause of death in these acute studies was generally attributed to the pyretic effect of 2,4-DNP, produced by an increase in metabolic rate. In one study, the authors indicated that rats treated once by gavage either died within 1-2 hours or recovered completely (Spencer et al. 1948). In an LDsotest,... 

DNP at 3.5 mg/kg/day 2,4-DNP for 4-12 days (Stockton and Cutting 1934). Systolic and diastolic blood pressures were not affected pulse rate increased as much as 12%. The changes in venous pressure and pulse rate tended to occur during episodes of peripheral vasodilatation and appeared, therefore, to be compensatory mechanisms for the maintenance of normal blood pressure. The episodes of peripheral vasodilation may have been a cooling response to the pyretic effects of... 

---