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Pulsatile release, hormone

Levine JE, Chappel P, Besecke LM, Bauer-Dantoin AC, Wolfe AM, Porkka-Heiskanen T, Urban JH (1995) Amplitude and frequency modulation of pulsatile luteinizing hormone-releasing hormone release. Cell Mol Neurobiol 15 117-139... [Pg.145]

Navarro CE, Abdul Saeed S, Murdock C, Martinez-Fuentes AJ, Arora KK, Krsman-ovic LZ, Catt KJ (2003) Regulation of cyclic adenosine 3, 5 -monophosphate signaling and pulsatile neurosecretion by G,-coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing hormone neurons. Mol Endocrinol 17 1792-... [Pg.146]

Terasawa E (2001) Luteinizing hormone-releasing hormone (LHRH) neurons mechanism of pulsatile LHRH release. Vitam Horm 63 91-129... [Pg.150]

The three best-known examples of biochemical oscillations were found during the decade 1965-1975 [40,41]. These include the peroxidase reaction, glycolytic oscillations in yeast and muscle, and the pulsatile release of cAMP signals in Dictyostelium amoebae (see Section V). Another decade passed before the development of Ca " " fluorescent probes led to the discovery of oscillations in intracellular Ca +. Oscillations in cytosolic Ca " " have since been found in a variety of cells where they can arise spontaneously, or after stimulation by hormones or neurotransmitters. Their period can range from seconds to minutes, depending on the cell type [56]. The oscillations are often accompanied by propagation of intracellular or intercellular Ca " " waves. The importance of Ca + oscillations and waves stems from the major role played by this ion in the control of many key cellular processes—for example, gene expression or neurotransmitter secretion. [Pg.261]

Gonadotropin-releasing hormone is secreted by neurons in the hypothalamus. It travels through the hypothalamic-pituitary venous portal plexus to the anterior pituitary, where it binds to G protein-coupled receptors on the plasma membranes of gonadotroph cells. Pulsatile GnRH secretion is required to stimulate the gonadotroph cell to produce and release LH and FSH. [Pg.837]

Luteinizing hormone-releasing hormone (LHRH) is used in the treatment of infertility (1). It induces pulsatile release of gonadotropin, and excessive stimulation can... [Pg.200]

Estes, K.S. and J.W. Simpkins (1982). Resumption of pulsatile luteinizing hormone release after a-adrenergic stimulation in aging constant estrous rats. Endocrinology. Ill 1776-1784. [Pg.409]

Before we can start to develop a model we also have to decide how to interpret the behavior observed in Fig. 2.1. The variations in insulin and glucose concentrations could be generated by a damped oscillatory system that was continuously excited by external perturbations (e.g. through interaction with the pulsatile release of other hormones). However, the variations could also represent a disturbed self-sustained oscillation, or they could be an example of deterministic chaos. Here, it is important to realize that, with a sampling period of 10 min over the considered periods of 20-24 h, the number of data points are insufficient for any statistical analysis to distinguish between the possible modes. We need to make a choice and, in the present case, our choice is to consider the insulin-glucose regulation to operate... [Pg.37]

In general, secretion of hormones does not occur at a constant rate. In some cases, secretion is pulsatile, occurring in short bursts, as for many pituitary hormones. The biochemical basis of this pulsatile release is not fully understood, but the release pattern may have profound effects on hormone function, i.e., the pulsatile administration of luteinizing hormone releasing hormone (LHRH) stimulates the release of LH by the pituitary, whereas the constant infusion of the same amount of hormone per unit time has the opposite effect. [Pg.128]

The anterior pituitary releases GH in 6 to 8 pulsatile bursts over a 24 h period the major portion is released just prior to deep sleep. Its secretion is controlled by hypothalamic peptides GH-releasing hormone stimulates GH secretion, while somatostatin inhibits it. GH stimulates the synthesis of insulin-like growth factor-1 (IGF-1 somatomedin C) mainly, but not solely, in the liver. GH and IGF-1 receptors are widely scattered throughout the body, and both hormones exert important metabolic actions in various tissues, especially muscle and bone. [Pg.43]

Luteinizing hormone-releasing hormone (LHRH) is used in the treatment of infertility (1). It induces pulsatile release of gonadotropin, and excessive stimulation can result. However, if used over a period of time, the receptors cease to respond and there can be a fall in the concentrations of luteinizing hormone and follicle-stimulating hormone and a fall in sex steroid concentrations to the castrato range. [Pg.1536]

JafTe, R.B. et a/. (1990) Neuromodulatory regulation of gonadotrophin-releasing hormone pulsatile discharge in women. Am. J. Obstet. Gynecol. Suppl.. 163. 1727-1731. [Pg.165]


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See also in sourсe #XX -- [ Pg.372 ]




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