Psychoactive effects intoxication

The involvement of the cerebellum in the psychoactive effects of marijuana and in changes in rCMR is consistent with the view that THC interacts with the high concentration of CB1 receptors in this brain area. Decreases in the cerebellar rCMR in habitual marijuana users may reflect the effects of chronic exposure to the drug. Functions known to be associated with the cerebellum, such as motor coordination, proprioception, and learning, are adversely affected both during acute marijuana intoxication and in habitual users. 

Of course, there is the question whether this substance contributes to the psychoactive effects of Inocybe aeruginascem. It is remarkable that all cases of involuntary intoxication... 

The psychoactive effects of Ascora calamus in humans are not well documented, but there is limited evidence that the plant is used as an ingredient in intoxicating Indian ritual snuffs (de Smet, 1985), and the crude plant potentiates barbiturate and ethanol-induced sedation in mice (Anonymous, 1996). Cis-isoasarone is thought to be the component of calamus responsible for these sedative properties. 

Siegel, R. K. (1976) Herbal intoxication. Psychoactive effects from herbal cigarettes, tea and capsules. J. Amer. med. Ass., 236,473. 

Inhalant intoxication dehrium can occur as a consequence of disturbances in dopaminergic, glutamatergic, and GABAergic neu to transmission secondary to acute, high-level exposure to psychoactive ingredients in solvents such as toluene, trichloroethane, and trichloroethylene. Systemic effects of solvent inhalation such as cerebral hypoxia and/or metabolic acidosis may also be involved (Rosenberg 1982). Under these circumstances, inhalant intoxication dehrium develops over a short period of time (usually hours to days) and tends to fluctuate during the course of the day. Usually, the delirium resolves as the intoxication ends or within a few hours after cessation of use. 

A. Yes. It appears that number of different Salvia species have different forms of psychoactivity. In addition some other members of the mint family (to which genus Salvia belongs) are psychoactive ( psychoactive means that a substance effects mood, alertness, thinking, emotion, or perception, most psychoactive substances are not hallucinogenic), for example there is a Central Asian mint known as intoxicating mint (Lagochiles inebriens) whose leaves are reportedly toasted and then brewed into a sedative tea. 

The WHO define the psychic dependence as a sensation of absolute need and the psychological tendency to periodical or continuous use. Craving is defined as a very strong desire for a psychoactive substance or for the intoxicating effects of that substance. Pharmacological tolerance is the need to progressively increase the dose to be administered to achieve the desired effects. Addictive potential is the ability of a substance to determine tolerance and dependence. This potential is used as a risk index for the consumption of a substance. 

The Kava plant, Piper methysticum, has been used by Pacific Island societies for several thousand years to prepare an intoxicating ceremonial beverage renowned for its relaxing effects and purported health benefits <1997MI84>. The psychoactive principles extracted from the Kava root are a family of 15 ct-pyrone derivatives known as the kavalac-tones. The more prevalent of these include (+)-kavain 61, (+)-methysticin 62, yangonin 63, and their more saturated derivatives 64, 65, and 66, respectively. 

Psilocybe semilanceata is quite likely the most potently psychoactive mushroom among the European species. The impressive nature and rapid onset of the effects are reflected in the description of an intoxication from England cited above. These elements are also part of the following account, which details a mycologist s first self-experiment ... 

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