Psoriasis genetic factors

Psoriasis is a T-lymphocyte-mediated inflammatory disease that results from a complex interplay between multiple genetic factors and environmental influences. Genetic predisposition coupled with some precipitating factor triggers an abnormal immune response, resulting in the initial psoriatic skin lesions. Keratinocyte proliferation is central to the clinical presentation of psoriasis. [Pg.949]

Psoriasis is a complex and multifactorial disease due to the interaction between environmental factors (exogenous or endogenous antigens) and a specific genetic background. The antigens involved in disease development are not completely known or understood. ... [Pg.1769]

The disease appears to have a genetic basis with environmental factors, such as infections, emotional trauma or mechanical trauma, causing outbreaks in susceptible individuals. Psoriasis should be regarded as a chronic systemic disease, which can be associated with other chronic diseases such as heart disease, hypertension and diabetes and may reduce life expectancy. About 15% of people with psoriasis also have psoriatic arthritis (see Chapter 7, page 173). [Pg.140]