Pseudomonas aeruginosa Subject

These findings prompted the development and evaluation of the currently available form of inhaled tobramycin, which is sterile and free of preservatives. The benefit of maintenance therapy with this inhaled tobramycin is supported by the results from two 24-week, multicenter, randomized, double blind, placebo-controlled clinical trials [6]. In these studies, patients with cystic fibrosis were at least six years of age, with an FEVj between 25% and 75% predicted. All subjects had evidence of colonization with Pseudomonas aeruginosa. Exclusion criteria included an elevated serum creatinine or colonization with Burkholderia cepacia, which is typically resistant to tobramycin. Subjects in the active treatment arm received inhaled tobramycin 300 mg twice daily through... 

The carbohydrate binding of H. pylori is still a complex situation with many postulated receptors. The picture is further confounded by the use of different strains, phase-variation, and use of different methods. The complex carbohydrate recognition pattern identified might partly be a result of the intense research efforts directed towards H. pylori. A parallel case is the multiple adhesive mechanisms described for Pseudomonas aeruginosa, another bacterium subjected to intense studies [65, and references therein]. 

Figure 3 Schematic representation of proposed functions of the CFTR. The absence of a functional CFTR in cystic fibrosis has been shown to stimulate the activity of epithelial Na channels (ENaC), leading to the conclusion that CFTR serves to inhibit these channels in normal subjects. CFTR has also been shown to transport bicarbonate anion and reduced glutathione across the apical epithehal plasma membrane. Studies have also suggested that CFTR may serve as a receptor for Pseudomonas aeruginosa.

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