Pruritus antihistamines

Pharmacologic Therapy Topical emollients have been used as treatment for pruritus in patients with dry skin, but are often not effective in relieving pruritus associated with CKD. Antihistamines, such as hydroxyzine 25 to 50 mg or diphenhydramine 25 to 50 mg orally or intravenously, are used as... 

Whether due to their antihistaminic activity or their sedative side effects, pruritus caused by contact dermatitis can be relieved with the use of sedating oral antihistamines such as... 

Antihistamines are frequently used, but few clinical studies support their efficacy. A sedating antihistamine (e.g., hydroxyzine, diphenhydramine) can offer an advantage by facilitating sleep because pruritus is often worse at night. 

Hj antihistamines are clinically used in the treatment of histamine-mediated allergic conditions. Specifically, these indications may include allergic rhinitis, allergic conjunctivitis, allergic dermatological conditions (contact dermatitis), pruritus (atopic dermatitis, insect... 

Hypersensitivity reactions Allergic reactions occur in approximately 33% of patients. They are more common at the start of treatment, and occur as generalized rashes or drug fever. Discontinue treatment and reinstitute at a low dosage such as 250 mg/day, with gradual increases. Administering prednisolone 20 mg/day for the first few weeks of penicillamine therapy reduces the severity of these reactions. Antihistamines may control pruritus. 

Epinastine (Elestat) [Antihistamine] Uses Itching w/ allergic conjunctivitis Action Antihistamine Dose 1 gtt bid Caution [C, /-] Disp Soln SE Burning, folliculosis, hyperemia, pruritus, URI, HA, rhinitis, sinusitis, cough, pharyngitis EMS None OD Unlikely... 

The treatment should be causal, but symptomatic treatment is also important. Heat and dehydration should be counteracted as far as possible. Skin softeners without perfume and irritant ingredients should be used frequently to treat dry skin. A sedating antihistamine often alleviates the pruritus, especially at night. Local steroids have no place in treatment unless there are inflammatory skin changes. 

After treatment, use topical corticosteroids to decrease contact dermatitis, antihistamines for pruritus pruritus may continue for 4-6 wk... 

Mecfianism of Action A long-acting nonsedating antihistamine that competes with histamine for Hj-receptor sites on effector cells. Therapeutic Effect Prevents allergic responses mediated by histamine, such as rhinitis, urticaria, and pruritus. Pharmacokinetics ... 

Mechanism of Action A phenothiazine that acts as an antihistamine, antiemetic, and CNS-antipsychotiC typical hypnotic. As an antihistamine, inhibits histamine at histamine receptor sites. As an antiemetic, diminishes vestibular stimulation, depresses labyrinthine function, and acts on the chemoreceptor trigger zone. As a sedative-hypnotic, produces CNS depression by decreasing stimulation to the brainstem reticular formation. Therapeutic Effect Prevents allergic responses mediated by histamine, such as rhinitis, urticaria, and pruritus. Prevents and relieves nausea and vomiting. Pharmacokinetics ... 

It is antihistaminic agent having antiemetic, sedative, anticholinergic and local anaesthetic property. Used in anxiety, pruritus and dermatoses as an adjunct therapy in acute/ chronic alcoholism. 

Tacrolimus, sirolimus, antimetabolites e.g. methotrexate, antihistaminics for pruritus dermatitis, prednicarbate (DERMATOP), becaplermin, dapsone, thalidomide, cyclosporine, interferon... 

Pruritus is a common symptom in skin along with itching. Antihistaminics and hydrocortisone are very effective in pruritus due to inflammation. 

Antihistamines Pruritus (any cause), urticaria See also Chapter 16. 

A 19-year-old man developed generalized urticaria, intense pruritus, and mild bronchospasm 30 minutes after injecting cocaine for the third time. He had weals on the face, neck, arms, and chest, and scattered wheezing in the lungs. Urine toxicology screen was positive for cocaine metabolites. His symptoms resolved several hours after the administration of Hi receptor antihistamines and intravenous glucocorticoids. 

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