Proxymetacaine hydrochlorid

Common Name Proparacaine hydrochloride Proparakain hydrochloride Proximetacainum hydrochloride Proxymetacaine hydrochloride... 

Infra-red Spectrum. Principal peaks at wavenumbers 1213,1708, 1305, 1104, 1590, 1520 (proxymetacaine hydrochloride, KCl disk). 

Tolazoline Hydrochloride 178-185 Proxymetacaine Hydrochloride 185-192 Choline Theophyllinate... 

Proxymetacaine hydrochloride Minims Proxymetacaine Minims Proxymetacaine and Fluorescein Local anaesthesia POM medicine for administration (not for sale or supply)... 

Examples Ethyl-p-amino benzoate Butamben Orthocaine Procaine Hydrochloride Tetracaine Hydrochloride Butacaine Sulfate Cyclomethycaine Sulphate Proxymetacaine Hydrochloride Propoxycaine Hydrochloride Hexylcaine Hydrochloride, etc. 

H. Proxymetacaine Hydrochloride BAN, Proxymetacaine INN, Proparacaine Hydrochloride USAN,... 

In a preliminary study the anesthetic effect of proxymetacaine hydrochloride (5 mg/ml) was tested in 5 male and 5 female albino rabbits (White Himalayan). One drop of the anesthetic was instilled in one eye per animal. The contralateral eye was treated with physiological saline solution as control. Measurements were performed before treatment as well as 1,30, and 60 minutes after treatment. 

According to the results of the experimental studies and to the findings of Harris et al. the acute, transient reduction of the comeal sensitivity only in rabbits was considered not to be prohibitive for the further development of Azelastine ophthalmic solutions. Clinical phase I studies were performed, where special consideration was given to the measurement of the comeal sensitivity. As in rabbits also in man the positive reference test dmg proxymetacaine hydrochloride was able to induce a distinct and measurable local anesthesia with a fast onset of action and a duration of approximately 15-30 minutes. Azelastine ophthalmic solutions at concentrations of 0.05% and/or 0.1%, however, did not produce any changes of the comeal sensitivity after both single or repeated applications. Concerning these results it must especially be noted, that in human volunteers the more sensitive pa-... 

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