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Biomarkers miRNA

Key words Biomarkers, miRNA, In vitro, Leakage, Stress response, Inflammation... [Pg.459]

Ahmed FE. Role of miRNA in carcinogenesis and biomarker selection a methodological view. Expert Rev Mol Diagn. 2007 7 569-603. [Pg.311]

J, Agoulnik S, Byrne M et al (2013) Circulating miRNA biomarkers for Alzheimer s disease. PLoS One 8 e69807. doi 10.1371/journal.pone.0069807... [Pg.526]

Urinary biomarkers Urine SCr, BUN, Kim-1, CysC, NGAL, miRNAs, etc. Extracellular medium Kim-1, CysC, NGAL, miRNAs, etc. [Pg.164]

Further validation of these potential retinal miRNA biomarkers will be needed in additional toxicological species, for example, dog and monkey, following treatments with a variety of retinal toxicants, as well as possible studies in laser-induced choroid neovascularization (CNV) and streptozotocin-induced diabetic retinopathy ocular disease models (Rittenhouse et al., 2014). Understanding the temporal and spatial relationships between retinal injuries and circulating miRNAs will be critical to fuUy understand the specificity, sensitivity, predictivity, and reliability of these biomarkers. Further evaluation of the translatability of circulating miRNA toxicity biomarkers in humans will be exciting as the next tier of retinal miRNA biomarker research. Finally, in addition to retinal miRNA biomarkers, there is the need to establish and validate other ocular tissue-specific miRNA biomarkers, for cornea, iris/ciliary body, and lens. [Pg.210]

The authors would like to thank Jianying Wang for her contributions to the discussion of miRNA biomarkers and Robert Mauthe for his review of the manuscript. [Pg.258]

E. Bertini, and I. Bozzoni (2011). miRNAs as serum biomarkers for Duchenne muscular dystrophy. EMBO Mol Med 3(5) 258-265. [Pg.413]

The evaluation of urinary microRNAs (miRNAs) as potential biomarkers of nephrotoxicity in NHPs is a recent advancement in discovery toxicology. Human TaqMan ... [Pg.447]

Low Density Array (TLDA) cards contain miRNA probes which may be used when profiling miRNAs in Cynomolgns monkey, while next-generation sequencing (NGS) appears to be a more comprehensive approach for this purpose. Preliminary results obtained in the context of consortia like the HESl Biomarkers of Nephrotoxicity Committee and the PSTC NWG have shown that urinary miRNAs could potentially be used as sensitive biomarkers of nephrotoxicity in NHPs and support translation across species. [Pg.447]

Kanki, M., et al.. Identification of urinary miRNA biomarkers for detecting cisplatin-induced proximal tubular injury in rats. Toxicology, 2014. 324 p. 158-68. [Pg.451]

Mall, C., et al.. Stability of miRNA in human urine supports its biomarker potential. Biormirk Med, 2013. 7(4) p. 623-31. [Pg.451]

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