Cartilage, proteoglycan

Proteoglycans may be soluble and located in the extracellular matrix, as is the case for serglycin, versican, and the cartilage matrix proteoglycan, or they may be integral transmembrane proteins, such as syndecan. Both types of proteoglycan... 

Secreted or extracellular matrix proteoglyeans Large aggregating cartilage proteoglycans CS/KS 220,952 2124... 

FIGURE 9.34 Hyaluronate (see Figure 7.33) forms the backbone of proteoglycan structures, such as those found in cartilage. 

Figure 48-6. Dark field electron micrograph of a proteoglycan aggregate in which the proteoglycan subunits and filamentous backbone are particularly well extended. (Reproduced, with permission, from Rosenberg L, Heilman W, Kleinschmidt AK Electron microscopic studies of proteoglycan aggregates from bovine articular cartilage. J Biol Chem 1975 250 1877.)...

Proteoglycans linked to chondroitin sulfate by the Xyl-Ser O-glycosidic bond are prominent components of cartilage (see below). The repeating disaccharide is similar to that found in hyaluronic acid, containing... 

In various types of arthritis, proteoglycans may act as autoantigens, thus contributing to the pathologic feamres of these conditions. The amount of chondroitin sulfate in cartilage diminishes with age, whereas the amounts of keratan sulfate and hyaluronic acid increase. These changes may contribute to the development of osteoarthritis. Changes in the amounts of cer-... 

CS-PG, chondroitin sulfate-proteoglycan these are similar to the dermatan sulfate PGs (DS-PGs) of cartilage ffable 48-11). SPARC, secreted protein acidic and rich in cysteine. 

THE MAJOR COMPONENTS OF CARTILAGE ARE TYPE II COLLAGEN CERTAIN PROTEOGLYCANS... 

Bone and cartilage are speciahzed forms of the ECM. Collagen I and hydroxyapatite are the major constituents of bone. Collagen II and certain proteoglycans are major constiments of cartilage. 

ADCOCKS c, COLLIN P and BUTTLE D J (2002) Catechins from green tea Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type 11 collagen degradation in vitro , JNutr, 132 (3), 341-6. 

Greenwald, RA., Moy, W.W. and Lazarus, D. (1976). Degradation of cartilage proteoglycans and collagen by superoxide anions. Arthritis Rheum. 19, 799-806. 

Fig. 4.—Structural Model of Bovine Nasal-Cartilage, Proteoglycan Complex. [-------,...

Brewer and Keiser160 investigated the 13C-n.m.r. spectra of bovine nasal-cartilage and its component sulfate polysaccharides (see Fig. 4). It consists of 75% of water and equal proportions of proteoglycan com-... 

---