Proteoglycan aggregate, cartilage

Secreted or extracellular matrix proteoglyeans Large aggregating cartilage proteoglycans CS/KS 220,952 2124... 

Figure 48-6. Dark field electron micrograph of a proteoglycan aggregate in which the proteoglycan subunits and filamentous backbone are particularly well extended. (Reproduced, with permission, from Rosenberg L, Heilman W, Kleinschmidt AK Electron microscopic studies of proteoglycan aggregates from bovine articular cartilage. J Biol Chem 1975 250 1877.)...

Figure 4-16 (A) Dark field electron micrograph of a proteoglycan aggregate from bovine articular cartilage (from bearing surfaces of joints). Courtesy of Joseph A. Buckwalter. The filamentous backbone consists of hyaluronic acid, as in (B). The proteoglycan subunits extend from the backbone. From Rosenberg.149...

Figure 9.14 Proteoglycan aggregate found in cartilage. C and N are C and N termini of the core protein. Long wavy lines represent chondroitin sulfate, whereas the short lines represent keratan sulfate. All are linkied to the core protein via the O-serine linkage, except for a few oligosaccharide chains near the N terminus of the core protein. LP is link protein, and HA is hyaluronic acid. (Reproduced by permission from Hascall V. Introduction. Functions of the Proteoglycans, Ciba Foundation Symposium 124. New York Wiley Sons, 1986, p. 2.)...

Fig. 5-23 A diagrammatic representation of part of a proteoglycan aggregate from cartilage.

Proteoglycan aggregate of cartilage, consisting of a hyaluronic acid (hyaluronate, HA) chain to which proteoglycan molecules are bound non-covalently. [Reprinted by permission from reference [4, Fig. 15]... 

Buckwalter JA, Pita JC, Muller FJ, Nessler J. Structural differences between two populations of articular cartilage proteoglycan aggregates. J Orthop Res... 

Roughley PJ, Poole AR, Mort JS. The heterogeneity of link proteins isolated from human articular cartilage proteoglycan aggregates. J Biol Chem 1982 257 11908-11914. 

Figure 32 Brush-like hierarchy of proteoglycan aggregate in cartilage (a) TEM micrograph of the aggregate (b) protein backbone with glucosami-noglycan side chains and (c) chemical structure of the disaccharide repeating unit of the side chains. Reprinted from Seog, J. Dean, D. Plaas, A. H. K. etal. Macromolecules 2002, 35 (14), 5601-5615, with permission from ACS. °...

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