Repeating disaccharide

FIGURE 7.33 Glycosamiooglycaos are formed from repeating disaccharide arrays. Glycosamiooglycaos are compooeots of the proteoglycans. 

The Glycosaminoglycans Found in Proteoglycans Are Built Up of Repeating Disaccharides... 

Hyaluronic acid consists of an unbranched chain of repeating disaccharide units containing GlcUA and GlcNAc. Hyaluronic acid is present in bacteria and is widely distributed among various animals and tissues, including synovial fluid, the vitreous body of the eye, cartilage, and loose connective tissues. 

Proteoglycans linked to chondroitin sulfate by the Xyl-Ser O-glycosidic bond are prominent components of cartilage (see below). The repeating disaccharide is similar to that found in hyaluronic acid, containing... 

The repeating disaccharide contains glucosamine (GlcN) and either of the two uronic acids (Figure 48-9). Most of the amino groups of the GlcN residues are N-sulfated, but a few are acetylated. The GlcN also carries a Cg sulfate ester. 

Figure 48-9. Structure of heparin. The polymer section illustrates structural features typical of heparin however, the sequence of variously substituted repeating disaccharide units has been arbitrarily selected. In addition, non-O-sulfated or 3-0-sulfated glucosamine residues may also occur. (Modified, redrawn, and reproduced, with permission, from Lindahl U et al Structure and biosynthesis of heparin-like polysaccharides. Fed Proc 1977 36 19.)...

Name Abbreviation Major uronic acidfe and hexosamine Main repeating disaccharides... 

The primary structure of chondroitin 4-sulfate is the repeated disaccharide... 

Section 12.8). Polymers of this kind are known as anionic mucopolysaccharides, or glycosaminogly-cans. Heparin consists of two repeating disaccharide... 

Figure 4-11 The repeating disaccharide units of hyaluronan and other glycosaminoglycans. See Fransson108 and Hardingham and Fosang.107...

The repeating disaccharide unit of the main chain of chondroitin sulfate is 50, with O-sulfo groups on the 4- or 6-hydroxyl groups of most 2-acetamido-2-deoxy-D-galactosyl residues. Fractions can be prepared... 

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