Proteins medically important

Dextran can be produced in a range of molecular weights and crossed-linked or substituted with a variety of functional groups. These products (Sephadex) are routinely used in the purification of proteins and pharmaceutical and other medically important compounds. 

Production of medically important polypeptides and proteins 7 Further reading... 

Sletta, H., Aune, R., Nedal, A. etal. (2007) The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Pichia pastoris. Applied and Environmental Microbiology, 73 (3), 906-912. 

Using the same logic, the PTO has granted patents, for example, for pure cultures of specific microorganisms and for medically important proteins (e.g. Factor VIII purified from blood (Chapter 12) and EPO purified from urine (Chapter 10)). 

Abstract Membrane proteins represent an important and challenging frontier in structural biology they mediate fundamental and medically important processes but are challenging targets for structure/ function studies. Magic angle spinning solid-state NMR methods for structure determination of proteins have developed rapidly in... 

The number of myristoylated proteins identified in viruses is constantly increasing. Nevertheless, substantial additional work will be required to shed light on the multiple functions that could be executed by the respective proteins as well as their involvement in the viral life cycle and elucidation of the role of the lipid anchor. Inhibition of NMT or replacing myristic acid by analogs in infected cells is known to affect numerous viruses of medical importance, for example, HIV (Bryant et al. 1989), hepatitis B virus (Parang et al. 1997), herpesviruses (Harper et al. 1993), and... 

Leucine aminopeptidase (LAP, E.C.3.4.11.1) is one of the first discovered and the most widely studied aminopeptidase with respect to sequence, structure and mechanism of action.59 -63 LAP is a zinc containing exopeptidase that catalyzes the removal of amino acids from the N-terminus of peptides or proteins. Similar to other aminopeptidases, this enzyme is of significant biological and medical importance because of its key role in protein modification, activation, and degradation as well as in the metabolism of biologically active peptides and activity regulation of hormonal... 

A Brief List of Medically Important Proteins Produced by Genetic Engineering... 

Chemokines are a large family of proteins that mediate the directed migration of leukocytes in the body. The moderate size ( 70 amino acids) and medical importance of these proteins have made them an attractive target for chemical... 

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