Proteins general information

To conclude, although the models used in lattice simulations are very simplified, the results provide general information on possible protein folding scenarios, albeit not on the detailed behavior of specific proteins, which would require more complex models and more accurate potentials. The contribution made by these simulations is that they enable an analysis of the structures, energetics, and dynamics of folding reactions at a level of detail not accessible to experiment. 

REMARK lines, containing (1) references to journal articles about the structure of this protein and (2) general information about the contents of this file, including many specifics about refinement methods and final criteria of model quality (see Chapter 8). 

Each SWISS-PROT entry consists of general information about the entry (e.g., entry name and date, accession number), Name and origin of the protein (e.g., protein name, EC number and biological origin), References, Comments (e.g., catalytic activity, cofactor, subuit structure, subcellular location and family class, etc.), Cross-reference (EMBL, PIR, PDB, Pfam, ProSite, ProDom, ProtoMap, etc.), Keywords, Features (e.g., active site, binding site, modification, secondary structures, etc.), and Sequence information (amino acid sequence in Swiss-Prot format, Chapter 4). 

RCSB Protein Data Bank. Nature of 3D Structural Data, http //www.rcsb.org/pdb/static.do p=general information/about pdb/nature of 3d structural data.html. 

For a protein substance, the complete mature amino acid sequence in a format that can be copied for analysis (Word or in the text of an e-mail) and with spaces between groups of 10 characters, and the sequence length the general information on disulfides and all post-translational modification. 

Fig. 3. A mechanism-based toxicity (MBT) curation tool was divided into four panels with (a) general information, (b) metabolism of the molecule, (c) biological data, and (d) toxicity data. The general information panel describes the structure, IUPAC name, smiles of the molecule, and the information on metabolites, their structures and any references. The panel on metabolism describes the toxicity information on individual metabolites and the references from which the information was curated. Biological data give the information on which protein or cells or organs get affected and the measurement of the effect. Toxicity panel gives the information on the molecule as well as the metabolites effect on the species, exposure times, measurement type and their values, effects, and the references.

Sites containing general information about proteins http //www. expasy.ch/ http //www.proweb.org/... 

The tertiary structure of a protein refers to the arrangement of amino acid side chains in the protein. Generally, the information for protein structure is contained within the amino acidjequence of the protein itself This important principle of biochemistry was first determined by the biochemist Christian Anfinsen in studies of the enzyme ribonu-clease. Ribonuclease catalyzes a simple hydrolysis of ribonucleic acid. The native enzyme has 124 amino acids 8 of these are cysteines, forming 4 disulfide bonds. When ribonuclease was treated with mercaptoethanol to destroy the disulfide bonds and urea to disrupt its secondary and tertiary structure, all enzymatic activity was... 

Fig. 3. General information for known SET domain and PRMT proteins ( undefined).

Egg white protein is considered to have one of the best amino acid profiles for human nutrition. Plant proteins generally have lower content of some essential amino acids such as lysine and methionine. Soy protein is one of the best plant proteins, but nevertheless, the most prominent difference in it is the proportion of the essential sulfur-containing amino acid methionine. Egg white protein has approximately three times more methionine than is found in soy protein. The yeast information is for brewer s yeast (Saccharomyces cervisiae). 

Although many new developments can be expected in the area of new radiopharmaceuticals based on larger substances such as proteins, cells, etc., we will confine the remainder of our discussion to the design of small molecules (molecular weight < 1000) for use as radiopharmaceuticals. In attempting to design radiopharmaceuticals of this type, it is useful to consider the general information which is known about factors which influence the biodistribution of small molecules. 

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