Protein-Nucleic Acid Interactions as a Basis for Specific Gene Regulation

Protein-Nucleic Acid Interactions as a Basis for Specific Gene Regulation [Pg.3]

In the following, the basic features of specific recognition of DNA sequences by DNA-binding proteins will be presented. [Pg.3]

The use of a particular mature mRNA for protein biosynthesis is also highly regulated. The regulation can occur via the accessibility of the mRNA for the ribosome or via the initiation of protein biosynthesis on the ribosome. In this manner a given level of mature mRNA can specifically determine when and how much a protein is synthesized on the ribosome. [Pg.3]

An imderstanding of the mechanism by which the highly specific and selective recognition of a nucleotide sequence is achieved is only possible with knowledge of the structural details of specific protein-nucleic acid complexes. For the regulation of gene activity the binding of proteins to double-stranded DNA is of central importance. We [Pg.3]

The current structural information on specific protein-DNA complexes allow the first answers to the following basic questions [Pg.4]

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