Protein domains exon encoding

Bourbon H, Bugler B, Caizergues-Ferrer M, Amalric F (1983) Role of phosphorylation on the maturation pathways of a 100 kDa nucleolar protein. FEBS Lett 155 218-222 Bourbon HM, Lapeyre B, Amalric F (1988) Structure of the mouse nucleolin gene. The complete sequence reveals that each RNA binding domain is encoded by two independent exons. J Mol Biol 200 627-638... 

Structural domains of proteins are sometimes encoded by a single coding segment of DNA i.e., by a single exon in a split gene. Domains of this type may have served as evolutionarily mobile modules that have spread to new proteins and multiplied during evolution. For example, the immunoglobulin structural domain is found not only in antibodies but also in a variety of cell surface proteins.229 252... 

Many exons encode protein domains Section 5,6.2... 

RNA Processing Generates Niature RNA Many Exons Encode Protein Domains... 

How might the fact that some exons encode discrete functional domains in proteins be related to the evolution of new proteins ... 

Exons often encode protein domains. Genetic recombination can lead to rearrangements in the order of exons in a gene. Upon expression, such rearranged genes could give rise to proteins with new domain orders and possibly new capabilities (text, pp. 137-138). 

Figure 11. Organization of the exons encoding the serine protease domains of several proteins. Abbreviations used are the same as in the legend to Figure 4. References for the genes for the pancreatic proteases, kallikrein, nerve growth factors, haptoglobin and complement factor B can be found in reference 83. See text for the other references.

This section provides data on specific transcripts and proteins, including which protein is encoded by which transcript, transcript exon structure, protein domains, and subcellular localization. Expression pattern data (including Northern and Western blot data as well as in situ hybridization and antibody staining data) are presented both in a tabulated form using a controlled vocabulary format and in a detailed free-text format. An image-based expression pattern search tool, which can access data captured in the controlled vocabulary format, is being developed. 

Eight exons of the AR gene encode a protein of around 917 aa depending on two polymorphic regions of polyglutamines (CAG) and polyglycines (GGN) in the N-terminal activation domain. Two isoforms are detected in tissues the predominant (80%) 110 kD (B isoform) and 87 kD (A isoform). It is not clear whether the two isoforms also serve different functions. 

All elastic proteins contain distinct domains, of which at least one is made up of elastic repeat sequences, and they all contain cross-links between residues in either the nonelastic or elastic domains [9]. Previously, the Drosophila CGI5920 gene was tentatively identified as one encoding a resUin-like protein [31]. To prepare recombinant resilin, we chose to express the first exon of the Drosophila CG15920 gene [29], which encodes an N-terminal domain in the native protein comprising 17 copies of the putative elastic repeat motif GGRPSDSYGAPGGGN [31]. 

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