Prostate cancer stromal tissue

We generated the input data for the absolute values of amplifudes based on fhe mean metabolite concentrations and also the description of mulfiplets and the total shape spectra for normal prosfafe tissues (glandular and stromal) and for the prostate cancer from Ref. [54]. We split the total metabolite concentrations into multiplets with the aim of attaining correspondence to the spectra of Ref. [54]. 

Normal glandular and normal stromal prostate show markedly different spectral patterns. Most notably, the resonances are much smaller in the stromal tissue. Lactate at 1.33 ppm and creatine at 3.04 ppm are the most prominent structures. The lactate peaks at 1.33 and 4.12 ppm are larger in the prostate cancer spectra compared with the two normal prostate tissues. The choline components at 3.21-3.24 ppm (i.e., total choline) are more abundant than creatine at 3.04 ppm. The spectrum for prostate cancer differs most clearly from that of normal glandular prostate, particularly in the spectrum for prostate cancer the citrate doublet peaks and the two polyamine resonances are much smaller than the components of choline. 

It is well established that chemokines play a critical role in inflammation and immunity. Interactions between chemokines and their receptors are essential for the inflammatory pathway, but it is now appreciated that the chemokine receptor system can be altered dramatically in neoplastic tissue. Moreover, chemokines induce direct effects on stromal and prostate cancer cells in addition to their roles in regulating leukocyte recruitment. 

In Tables 6.9, 6.10, and 6.11, the input data for the normal glandular, for normal stromal prostate, and for prosfafe cancer are presenfed. The spectral parameters co, d (1 time signal. No editing or other modification is performed. We computed the kth metabolite concentration of the tissue wet weight from the absolute value d of the reconstructed amplitude d as Cj = dj C,ef/2 = 5.465 d /xM/g ww. 

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