Stromal prostate, normal

In Tables 6.9, 6.10, and 6.11, the input data for the normal glandular, for normal stromal prostate, and for prosfafe cancer are presenfed. The spectral parameters co, d (1 time signal. No editing or other modification is performed. We computed the kth metabolite concentration of the tissue wet weight from the absolute value d of the reconstructed amplitude d as Cj = dj C,ef/2 = 5.465 d /xM/g ww. 

Table 6.10 Input data for normal stromal prostate spectral parameters and metabolite concentrations based on In vitro data of Ref. [54].

Absorption Component Shape Spectra Normal Stromal Prostate Tissue... 

Figure 6.21 Absorption component spectra for normal stromal prostate as reconstructed by the FPT at Np = 54 (top panel (i)) and Np = 800 (bottom panel (ii)), based on in vitro MRS data from Ref. [54].

The absorption component shape spectra for normal glandular prostate (upper panel (i)), normal stromal prostate (middle panel (ii)), and prostate... 

Normal glandular and normal stromal prostate show markedly different spectral patterns. Most notably, the resonances are much smaller in the stromal tissue. Lactate at 1.33 ppm and creatine at 3.04 ppm are the most prominent structures. The lactate peaks at 1.33 and 4.12 ppm are larger in the prostate cancer spectra compared with the two normal prostate tissues. The choline components at 3.21-3.24 ppm (i.e., total choline) are more abundant than creatine at 3.04 ppm. The spectrum for prostate cancer differs most clearly from that of normal glandular prostate, particularly in the spectrum for prostate cancer the citrate doublet peaks and the two polyamine resonances are much smaller than the components of choline. 

Figures 6.29 and 6.30, respectively, show the converged absorption component and total shape spectra for normal glandular prostate (upper panels (i)), normal stromal prostate (middle panels (ii)), and prostate cancer data (lower panels (iii)) within the spectral region between 2.40 and 3.70 ppm at Np = 800. The component spectra clearly distinguish PCho and GPC, which is not the case for the total shape spectra.

For these prostate spectra, theoretically it would be possible to retrieve all 27 input resonances at Np = 54, since there are 54 unknowns (27 complex frequencies and 27 complex amplitudes) with 54 linear equations and 54 signal points needed. In fact, at Np = 54, precisely 27 resonances were retrieved. However, 15 of fhese were spurious for the normal glandular prostate, and 16 were spurious for the normal stromal prostate and malignant prostate. The pole-zero cancellations with zero-valued amplitudes were used to identify these resonances as spurious. 

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