Prostate cancer phytoestrogens

Prostate Cancer. Evidence that phytoestrogens can influence the incidence of male-speciflc diseases is restricted to prostate cancer, and is largely of an observational nature. In the UK, prostate cancer is the most common hormone-related cancer in men. However, like breast cancer in women, it is comparatively rare as a clinically evident disease in men living in Asian countries. 

In order to get recent advances on the effects of phytoestrogens on hormonal-dependent diseases as well as on human supplementation trials, it might be useful to refer to http //www.venus-ca.org/ (EU-funded project on dietary exposure to phytoestrogens and related compounds and effects on skeletal tissues) http //www.phytos.org (EU-funded project on the prevention of osteoporosis by nutritional phytoestrogens) http //www.phytoprevent.org (EU-funded project on the role of phytoestrogens in the prevention of breast and prostate cancer) and http //www.nutrition.tum.de/isoheart.htm (EU-funded project on cardiovascular health of postmenopausal women). 

CAG repeat length. Shorter CAG repeat sequences have been found in African Americans. Therefore, the combination of increased testosterone and increased androgen receptor activation may account for the increased risk of prostate cancer for African-American men.2 The Asian diet generally is considered to be low in fat and high in fiber with a high concentration of phytoestrogens, potentially explaining the decreased risk in Asians.4... 

Holzbeierlein JM, McIntosh, Thrasher JB. The role of soy phytoestrogens in prostate cancer. Curr. Opin. Urol 15, 17-22, 2005. 

Shenouda NS, Zhou C, Browning JD, Ansell PJ, Sakla MS, Lubahn DB, Macdonald RS. 2004. Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer 49 200-208. 

Stephens, F. O., Phytoestrogens and prostate cancer Possible preventative role. Med. J. Austral. 167, 138-140 (1997). 

Strom, S. S., Yamamura, Y., Duphome, C. M., Spitz, M. R., Babaian, R. J., etal., Phytoestrogen intake and prostate cancer A case-control study using a new database. Nutr. Cancer 33, 20—25 (1999). 

Stephens, F.O. 1999. The rising incidence of breast cancer in women and prostate cancer in men. Dietary influences a possible preventive role for nature s sex hormone modifiers—the phytoestrogens (review). Oncol. Reports. 6 865-870. 

Suppression of prostate cancer progression in transgenic mice by resveratrol was reported [24]. Male mice with transgenic adenocarcinoma of the prostate were fed resveratrol (625 mg resveratrol/kg AIN-76A diet) and phytoestrogen-free control diet (AIN-76A) starting at 5 weeks of age. Mechanisms of action and histopathologic studies were conducted at 12 and 28 weeks of age, respectively. Resveratrol in the diet significantly reduced the incidence of poorly differentiated prostatic adenocarcinoma... 

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