24-propyl cholesterol

The configuration at C-24in 24-propyl cholesterol 347 extracted from Texas brown tide, was established through a synthesis using in a main step a Claisen-Johnson rearrangement applied to allylic alcohol 348 [80] ( Scheme 6.58). 

Abbreviations. HA, hemagglutinin DRV, dehydration-rehydration vesicles PC, phosphatidylcholine DOPE, dioleoyl phosphatidylcholine DOTAP, l,2-dioleyloxy-3-(trimethylamonium propane) BisHOP,, 2-bis (hexadecylcycloxy)-3-trimethylamino propane DC-CHOL, 3p(V,V,-dimethylami-noethane)-carbamyl cholesterol (DC-CHOL) DOTMA, V-[l-(2,3-dioleyloxy) propyl]-iV,V,V-triethylammonium PG, phosphatidyl glycerol PS, phosphatidylserine SA, stearylamine DODAP, l,2-dioleyloxy-3-(dimethylamonium propane). 

Figure 2 Examples of cationic lipids, differing in the head group structure (mono/ poly cationic) and the nonpolar lipid anchor (Chol/hydrocarbon chains). Abbreviations DOTAP, A-[l-(2,3-dioleoyloxy)propyl]-A,A,7V-trimethyl-ammoniumchloride DOTMA, A-[l -(2,3-dioleyloxy)propyl]-A A, A-trimethylammoniumchloride DC-Chol, 3 P"[A-(A, A -dimethylaminoethyl)carbamoyl]-cholesterol DOGS, A, A-dioctodecyl-amidoglycylspermin DORI, A-(l, 2-dioleoyloxypropyl)-A,A-dimethyl-A-hydroxyethyl-ammoniumbromide SpdC, spermidin-cholesterol.

Abbreviations DOPE, l,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine DOTAP, iV-[l-(2, 3-dioleoyloxy)propyl]-A,iV,JV-trrmethylanimoniumchloride TE, transfection efficiency DC, dendritic cells RLU, relative light units chol, cholesterol. 

DOTAP A-(l-(2,3-dioleoyloxy)propyl)-jV,jV,ALtrimethylammonium chloride DC-Chol 3 3[jV-(AUV -di methylaminoethane)carbamoyl]-cholesterol CCS ceramide carbomoyl spermine. 

Olefinic alcohols react smoothly with hydrogen over platinum oxide catalyst at room temperature. The procedure is illustrated by the preparation of dihydrocholesterol from cholesterol. Cinnamyl alcohol. CjH5CH = CHCH20H, is reduced to dihydrocinnamyl alcohol by lithium aluminum hydride. The reduction of allyl alcohol to n-propyl alcohol by the reagent, however, is unsatisfactory, ... 

CE CGE CHOL CIP CPG CTAB CZE dA, dG, dC DBU DEAE DMF DMT DNP DOPE DOTMA EDTA EM EOF ESI-MS Fmoc FPE ICAM-1 Capillary electrophoresis Capillary gel electrophoresis Cholesterol Cahn-Ingold-Prelog nomenclature system for absolute configuration Controlled pore glass Hexadecyltrimethylammonium bromide Capillary zone electrophoresis Deoxyadenosine, deoxyguanosine, deoxycytosine l,8-Diazabicyc o[5.4.0]undec-7-en Diethylaminoethyl- Dimethylformamide Bis(4-methoxyphenyl)phenylmethyl-, (syn. Dimethoxytrityl-) 2,4-DinitrophenyI- Dioleylphosphatidylethanolamine N-[l-(2,3-dioleyloxy)propyl]-N, N, N-trimethylammonium chloride Ethylenediamine tetra-acetic acid Electrophoretic mobility Electro-osmotic flow Electrospray ionization mass spectrometry 9-Fluorenylmethoxycarbonyl-Fluid phase endocytosis Intracellular Adhesion Molecule-1... 

Abstract. The binding properties of granular alginic acid(H-alg.) and chitin to iodine, bromine, cadmium ion, calcium ion and cholesterol were investigated. Chitin-iodine and chitin-bromine compounds closely resemble those of H-alg. The amount of iodine included by these polysaccharides increased with a decrease in the concentration of potassium iodide (KI). The number of sugar residues bound to one iodine molecule extrapolated to 0 g of KI was around 6.0 for H-alg. and 6.4 for chitin. These saccharides, which do not form a gel in water, were found to also absorb KI and radioactive iodide or iodine in aqueous solution. H-alg. did not show as much affinity to cadmium ion and calcium ion and cholesterol in iso-propyl alcohol as metal-alginates. 

Cholesterol... None of chitin was obtained pure, so the sample of chitin obtained from carapace was positive to the cholesterol E-Test and the extinction to standard cholesterol solution increased with an increase in the amount of chitin, but any reduction of cholesterol by chitin was not observed at all. In the previous experiment the removal of cholesterol from acetic acid solution by the addition of metal alginate beads was observed. Such reduction of cholesterol from iso-propyl alcohol by the addition of metal alginate beads (unpublished), H-alg. or chitin is not observed in this experiment, so it indicates that the removal of cholesterol from the acidic solution depends on the shrinkage of the metal alginate beads, but not on the fiber chain packing. 

Both isotopes in fatty acids. Iso- (212) propyl group more efficient source of carbons for cholesterol than acetate or carboxyl fragment of isovalerate... 

Fig. 3 Effect of cholesteryl ethers in liposomes prepared with DOPC on the relative amount of glucose released (A) (x) cholesterol (o) cholesteryl methyl ether ( ) cholesteryl ethyl ether (v) cholesteryl-n-propyl ether ( ) cholesteryl isopropyl ether (A) cholesteryl butyl ether (B) (x) cholesterol (o) cholesteryl (2 -hydroxy)-3-ethyl ether ( ) cholesteryl methoxy methyl ether ( ) cholesteryl acetate.

Ezetimibe is a dmg with cholesterol absorption inhibitor properties used to treat hypercholesterolemia. Its active form, (3R,4S)-l-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one, was successfully obtained via microbial diastereoselective reduction of (3R,4S)-l-(4-fluorophenyl)-3-[3-oxo-3-(4-fiuorophenyl)-propyl]-4-(4-hydroxyphenyl)azetidin-2-one using whole cells of Rhodococcus fascians M022 (Figure 13.5b) [19]. Conversion of 94% was obtained after 4h in highly diluted system (0.1 g/1 substrate) with 20% cell suspension, along with excellent de value (99.9%). 

Since 1983, researcher has been trying to develop and evaluate cationic lipids formulation for efficient gene transfer. N-[l-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTMA) [52], [l,2-bis(oleoyloxy)-3-(trimethylammonio)propane] (DOTAP) [53], 3P[N-(N, N -dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) [54], and dioctadecylamido glycylspermine (DOGS) [55] were widely used as a commercial reagent for cationic lipids. A neutral lipid, Dioleoylphosphatidylethanolamine (DOPE)is also often used in conjunction with cationic lipids to aid in endolysosomal escape [56]. 

DOTMA, l,2-dioleyl-3-iV,iV,iV-trimethylaminopropane chloride DC-Chol, 3-j8-[A-(A, A -dimethyl-ethane)carbamoyl]cholesterol DMDHP, ( )-N,N-[bis(2-hydroxyethyl)]-iV-[2,3-bis(tetradecanoyloxy)propyl]ammonium chloride DMRIE, l,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide DOTAP, l,2-dioleoyloxy-3-(trimethylamino)propane DHDEAB, A,A-di-n-hexadecyl-iVA -dihydroxyethylammonium bromide HDEAB, N-n-hexadecyl-iVA -dihydroxyethylammonium bromide MOOHAC, A-methyl-A- -octadecyl-iV-oleyl-iV-hydroxyethylammonium chloride DOMHAC, N-methyl-AA-di-n-octadecyl-iV-hydroxyethylammonium chloride DOHEMAB, A,A-di[0-hexadecanoyl]hydroxyethyl-A-hydroxyethyl-A-methylammonium bromide DOSPA, 2,3-dioleoyloxy-A-[2-(sperminecarboxamido)ethyl]-A,A-dimethyl-l-propanaminium trifluoroacetate DDAB, dioctadecyldimethylam-monimn bromide DOPE, l,2-dioleoyl-propyl-3-phosphatidylethanolamine. 

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