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Amitriptyline-N-oxide

Fi re 4.15 Separation of the tricyclic antidepressant amitriptyline and its major metabolites on a 10 cm x 4.6 mm I. D. column packed with Spherisorb S5H silica with methanol-aqueous ammonium acetate (9 1), pH 9.1, as mobile phase at a flow rate of about 1 ml/min. Peak identification 1 > amitriptyline-N-oxide 2 amitriptyline 3 - E-lO-hydroxyamitriptyline 4 - Z-10-hyroxyamitriptyline 5 desmethylnortrlptyline 6 nortriptyline 7 E-lO-hydroxynortriptyline and 8 - Z-lO-hydroxynortriptyline. (Reproduced with permission from ref. 271. Copyright Elsevier Scientific Publishing Co.)... [Pg.200]

Amitriptyline N-oxid, et nyt antidepressivum sammen-lignende klinisk vurdering i forhold til amitriptylin. [Amitriptyline N-oxide. A new antidepressant. A clinical double-blind comparison with amitriptyline.] Nord Psykiatr Tidsskr 1971 25(3) 237-46. [Pg.30]

C20H23NO amitriptyline-N-oxide 4317-14-0 25.00 1.0558 2 32354 C20H30O2 16-ethyl-17-hydroxyester-4-en-3-one 33765-68-3 25.00 0.9731 2... [Pg.283]

Hine papers on Amitriptyline-N-oxide, Arzneim.-Forsoh. 28, 1873-1926 (1978). [Pg.10]

Amitriptylinoxide. S-(I0,Il-Dihydro-5H-diben-zo[a,d]cyclohepten-S-yiidene)-N,N-dimethyl-l-propanamine N-oxide 10,ll-dihydro-N,H-dimethyl-5H-dibenzo[a,d]cyclo-heptene-A -propylamine N-oxide amitriptyline N-oxide Ambivalon Equilibrin. C H NO mol wt 293.41. C 81,87%. H 7.90%, N 4.77%, O 5.45%. Centrally acting metabolite of amitriptyline, q.v. Prepn J. B. Pedersen, Brit, pat. 991,651 corresp to IIS. pat. 3,299,139 (1965, 1967 both to Dumex). Series of articles on pharmacology, pharmacokinetics, metabolism, clinical studies, toxicity studies, terato-logical Studies Arzneimillel-Forsch. 28, 1873-1926 (1978). HPLC determn K. M. Jensen, J. Chromatog. 183, 321... [Pg.80]

Jensen, K.M. Determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma by hi -performance liquid chromatography. J.Chromatogr., 1980,183, 321-329... [Pg.86]

Riemann DS, Velthaus S, Laubenthal S, et al REM-suppressing effects of amitriptyline and amitriptyhne-N-oxide after acute medication in healthy volunteers results of two uncontrolled pilot trials. Pharmacopsychiatry 23 253-258, 1990... [Pg.733]

See other pages where Amitriptyline-N-oxide is mentioned: [Pg.5]    [Pg.5]    [Pg.205]    [Pg.15]    [Pg.24]    [Pg.24]    [Pg.288]    [Pg.491]    [Pg.517]    [Pg.446]   
See also in sourсe #XX -- [ Pg.5 ]



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