2-Hydroxy-3- propyl chloride

Quecksilber 3-Ethansulfonylamino-2-hydroxy-propyl- -chlorid XIII/2b. 163... 

Phosphontum Hydroxymethyl-tris-[3-chlor-2-hydroxy-propyl]-(chlorid) El. 555 [(HO-CH2)4P + subst. Oxiran]... 

Propanol 3-(Chlor-dibutyl-stannyl)-E19a, 894 (En-ol + R2SnH2) Zinn Bis-[2-methyl-propylj-(3-hydroxy-propyl)- -chlorid XIII/6, 283... 

The first step involves the preparation of 1 -(3-isobutoxy-2-chloro)propyl pyrrolidine as an intermediate. 345 ml of thionyl chloride dissolved in 345 ml of chloroform are added, drop by drop, to 275 g of 1 -(3-isobutoxy-2-hydroxy)propyl pyrrolidine dissolved in 350 ml of chloroform, while maintaining the temperature at approximately 45°C. The reaction mixture is heated to reflux until gas is no longer evolved. The chloroform and the excess of thionyl chloride are removed under reduced pressure. The residue is poured on to 400 g of crushed ice. The reaction mixture is rendered alkaline with soda and the resulting mixture is extracted twice with 250 ml of diethyl ether. The combined ethereal extracts are dried over anhydrous sodium sulfate. After evaporation of the solvent the residue is distilled under reduced pressure. 220 g of product are obtained having the following properties boiling point = 96°C/3 mm, n074 = 1.4575. 

Ethy I-p-hydroxy benzoate Cyclohexyl bromide 3-(2 -Methylplperidino)propyl chloride... 

Hydroxymethyl- -methylester 601 2-[2-(2-Hydroxy-phenyl)-athyIj- 767 -[l-hydroxy-propyl-(2)-amid] 212 -isopropylester-isopropylimid 359 2-Jod- 160 2-Jod- -chlorid 186... 

Hydroxy-3,4-dihydro-2H-pyrido[2,l-b][l,3]thiazin-5-ium chloride was formed when 2-hydroxy-3-(2-pyridylthio)propyl chloride was stirred in methylene chloride overnight (92JOC6335). When the reaction was carried out in methanolic sodium methylate, 3-(2-oxo-l,2-dihydro-l-pyridyl) thietane was obtained in 58% yield. 

Methyl magnesium chloride (3.0 Molar solution in THF, 790 mmol) was added dropwise over 30 min to the CeCI3 slurry at 0°C. After stirring 2 hours, the mixture was cooled to -5°C and a toluene (600 mL) solution of the ethyl 2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxy-propyl)benzoate (152 mmol) was added dropwise over 1 hour. The reaction mixture was stirred another hour before the addition of 2 M HOAc (600 mL) and toluene (600 mL). The organic layer was washed with saturated aq. NaHC03 and with brine. Concentration in vacuo and purification of the residue by flash chromatography (30% EtOAc in toluene) gave 63.48 g (91%) of the 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol. 

The use of hindered handles or functionalized solid supports would minimize piperazine-2,5-dione formation. Thus, the tertiary alcohol handle 4-(l, l -dimethyl-l -hydroxy-propyl)phenoxyacetic acid (DHPP, 1, Table and the 2-chlorotrityl chloride resin [Trt(2-Q)-C1 resin, are both very convenient for this purpose.t 1 An alternative proce-... 

Pyrrolo[l,2-a]indolequinones were prepared also by cyclization reactions. One of them involves copper-catalyzed pyrolysis of 2-azido-5-methoxy-6-methyl-3-(2,4-pentadienyl)-l,4-benzoquinone to give compound 45 (87JOC3956). The second pyrrole ring was also formed from a 2-hydroxy-propyl side chain of an indolo-4,7-dione (80JOC5057). Benzo analogs were prepared in a Friedel-Crafts reaction from either phthalic anhydride (67TL765) or 2-pyrrolidinylcarbonyl chloride (86H2797). 

Jen et al obtained a 1 2 mixture of the pyrroIo[l,2-a]quinazoline 123 and the pyrrolo[2,l-6]quinazoline 124 from the reaction of 2-(3-hydroxy-propyl)-3,4-dihydroquinazoline (122) with phosphoryl chloride under a nitrogen atmosphere. 

Journal of Applied Polymer Science 88, No.6, 9th May 2003, p. 1567-72 DURABLE ANTIMICROBIAL TREATMENT OF COTTON FABRICS USING N-(2-HYDROXY)PROPYL-3-TRIMETHYLAMMONIUM CHITOSAN CHLORIDE AND POLYCARBOXYLIC ACIDS Yotmg Ho Kim chang Woo Nam Jae Won Choi ... 

Methacholine Chloride. 2-(Acetyloxy -N,N,N-tri-mct hyl-1 -propana min i um chloride acetyl-0-methyicholine chloride O-acetyI-d-methylcholine chloride (2-hydroxy-propyl)trimethylammonium chloride acetate (2 Jacetoxy-propyl)trimethylammonium chloride trimethy] -i -acetoxy -propylammonium chloride Amechol Provocholine. C Hia-aNO, mol wt 195.69. C 49.10%. H 9.27%, Cl 18 ] 2%. N 7.16%, O 16.35%. Parasympathomimetic bronchoconstric-tor. Prepn from trimethylacetonylammonium chloride R. T. Major, J. K. Cline, L.S, pat. 2,040,146 (1936 to Merck Co.). Mechanism of ganglionic blockade in cats R. L. 

Propoxybenzoic acid is obtained by the interaction of / -hydroxy benzoic acid and -propyl chloride in an alkaline medium, whieh on nitration yields the corresponding 3-nitro analogue. Subsequent treatment with thionyl ehloride yields an aeid ehloride whieh is then eoupled with 2-(diethylamino) ethanol yields the proxymetacaine base. This on reaction with an equimolar quantity of HCl gives the official compoimd. 

Paint strippers are also formulated to have high viscosity, otherwise they run off vertical surfaces and thereby fail to penetrate or solubilise the paint to which they have been applied. Hydroxy-propyl methylcellulose is the main thickener for paint strippers, which use methylene chloride (dichloromethane) as the principal component. Hydroxypropyl methylcellulose is useful for this purpose because it is soluble in the organic component but is not sensitive to the presence of any water that may also be present in the paint stripper. 

However, one of the first matrices used for insolubilization of the aflBnant was cellulose that had been partially etherified with 3-hydroxy-phenoxy or 4-diazobenzyl groups (which react with diazotized protein or protein, respectively). Amino compounds may also be attached to the acid chlorides of carboxy polysaccharides.0-(3-Allyloxy-2-hydroxy-propyl)-cellulose and -Sephadex can be mercuriated and, in this form, used for isolation of thiolated antibodies and fractionation of mononucleotides according to their aflBnity for an organomercurial. Another mercurial, prepared by treatment of 0-(2-aminoethyl)Sephadex with IV-acetylhomocysteine thiolactone to give a thiol (49) which, on treatment with 2,5-bis[(acetoxymercuri) methyl]-1,4-dioxane, gives 50, can also be used in aflSnity chromatography of thiolated proteins. 

Substance/ ingredients per ml 20 mg methyl cellulosepropy) glyceroletheri sodium chloride potassium chloride, calcium chloride-2 HjO. lactic acid, hydrochloric add. sodium hydroxide methylhydroxy-propykeJlulose 18.0 to 22.0 mg, sodium chloride, potassium chloride, calcium chloride x lactic acid, hydrochloric acid, sodium hydroxide, water for injection 20 mg methyl-hydroxy propyl cellulose, 4.9 mg sodium chloride, 0.75 mg potassium chloride, 0.48 mg calciumchloride. 0.3 mg magnesium chloride, 3.9 mg sodium acetate, 1.7 mg sodium citrate, HCl/sodium hydroxid buffer solvent 20 mg methyl-hyd oxyp opyl-cellulose, 9 mg sodium chloride, 2.7 mg boric add, 0.2 mg sodium, aqua ad injectibila 20 mg methyl-hydroxy propyl-cellulose, 9 mg sodium chloride, 2.7 mg boric acid, 0.2 mg sodium, aqua ad injectibila 18 mg hydroxy-propy Im et hy Icell u 1 o se, 5.9 mg sodium chloride, 0.75 mg potassium chloride, 0.48 mg calcium chloride, 0.3 mg magnesium chloride, 3.9 mg sodium acetat, L7 mg sodium citrate... 

C W Nam, Y H Kim, S W Ko, Modification of pol rylonitrile (PAN) fiber by blending with At-(2-hydroxy)propyl-3-trimethyl- ammonium chitosan chloride , J of App... 

The effects of chitin and chitosan derivatives on in vitro human platelet activation were comparatively studied by Janvikul et al. (2006). Chitin, chitosan, partially A -acetylated chitosan (PNAC), A,0-carboxymethylchitosan (NOCC), Af-sulfated chitosan, and A-(2-hydroxy)propyl-3-trimeth-ylammonium chitosan chloride were tested for platelet aggregation assay. The results revealed that NOCC activated platelets most effectively. 

Figure 8. TEM picture owdng catalyst particles in poly(3-cliloro-2-hydroxy-propyl-2-methacryloxyeth>d-dimetliyl ammonium chloride). Polymer Pt = 25 1...

V-(2-Hydroxy)propyl-3-trimethyl-ammonium chitosan chloride or water soluble chitosan derivative / Polyacrylonitrile... 

Cationic Starches. Commercial cationic starches are starch ethers that contain a tertiary amino or quaternary ammonium group, eg, the diethylaminoethyl ether of starch or the 2-hydroxy-3-(trimethylammonio)propyl ether of starch [9063-45-0], sold as its chloride salt [56780-58-6]. 

After the electrolytic action. has continued for a suitable period, the contents of the vessel are allowed to cool, following which the unchanged nitro-cymene is separated for re-use, and the l-methyl-2-amino-4-iso-propyl-5-hydroxy benzol is filtered off from the remaining acid solution, whidh latter is strengthened for re-use. The l-methyl-2-amino-4-isopropyl-5-hydroxy benzol is then diazotised, and further reduced in an alkaline solution of stannous chloride, in the usual and well-known manner, with the resulting- production of thymol (l-methyl-4-isopropyl-5-hydroxy benzol). 

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