Oxetorone Fumarate

To make the hydrochloride salt, the bisacetamide or, by another name, 1,11-diphenyl-2,2,3,9,10,10-hexamethyl-4 3 liketo-6-(/3-hydroxy ethyl )-3,6,9-triazaundecane is dissolved In n-butanol. The solution is chilled and then dry hydrogen chloride gas is passed into the solution causing an oil to separate. To the heavy oil ether is added and then stirred causing crystallization to occur. MP146°Cto 147°C. Analysis for nitrogen calc. 8.3%, found 8.2%. 

To make the acetate salt, the bisacetamide (4.7 g) (0.01 mol) is dissolved in ethyl acetate to vuhich is added glacial acetic acid (OB g) (OjOI mol). Ether is added to precipitate the acetate as a gum vuhich is vuashed vuith hexane, and finally added to dry ether. Allovu to stand for crystallization. MP 141 °C. Analysis for nitrogen calc. 8.0% found 8.2%. 

Seifter, J., Hanslick, R.S. and Freed, M.E. U.S. Patent 2,780,646 February 5,1957.assigned to American Home Products Corp. 

Chemical Name 6-(3-Dimethylamino-1 -propylidene)-12H-benzofuro[26-e] benz[b] oxepin fumarate 

6-Oxo-benzo[b] benzofurano[26-e] oxepin Sulfuric acid Fumaric acid 

---

Amitriptylin oxide 3-(Dimethylamino) propyl chloride Amitriptyline HCI Ch/orprothixene Clomipramine Cyclobenzaprine Imipramine HCI Oxetorone fumarate Prothipendyl HCI... 

Gallamine triethiodide Ibuprofen Nalidixic acid Oxetorone fumarate Oxolinic acid Piroheptine Rosoxacin Tridihexethyl iodide Ethyl 4-iodobutyrate Meptazinol... 

---