Propionic 2,3-diamino

Diamino-propionic acid (DAPA) H2NCH2CH(NH2)C00H... 

Pyrimethamine Pyrimethamine, 2,4-diamino-5-(4 -chlorophenyl)-6-ethylpyrimidine (33.1.60), is synthesized from 4-chlorobenzycyanide, which upon condensation with methyl ester of propionic acid in the presence of sodium methoxide gives the 8-ketonitrile... 

Although the pK of the cy-amine group for Lys is within the titratable range and that for Arg would probably become so on coordination, the relatively long methylene chains render any tridentate chelation unlikely, and this appears to be the case.10- 4 The shorter methylene side chains in the synthetic diamine-monocarboxylates ornithine, 2,4-diaminobutanoic acid and 2,3-diamino-propionic acid lead to increased tridentate behaviour in that order. 

Propionic acid, a-[ 2-[(a-carboxy-2-hydroxybenzyl)-imino]ethyl imino]-metal complexes, 788 Propionic acid, 2,3-diamino-metal complexes, 750... 

D Fouques, J Landry. Study of the conversion of asparagine and glutamine of proteins into diamino-propionic and diaminobutyric acids using [bis(trifluoroacetoxy)iodo]benzene prior to amino acid determination. Analyst 116 529-531, 1991. 

There is, of course, no paucity of examples using heteroatom-based nucleophiles. For example, aziridine-2-/-butyl carboxylate 102 reacts with primary amines to give the dialkylated diamino-propionic acid derivatives 103, which are interesting precursors for the synthesis of cyclosporin analogs. Again, attack occurs overwhelmingly at the B-carbon [95TL4955]. 

S -(4-Hydroxybenzyl)-glutathione (phenolic peptide) i.-a-Amino-y-oxalylaminobutyric acid (amino acid) I.-3-Oxalylamino-2-aminopropionic acid (= 3-JVOxalyl-2,3-diamino propionic acid (3-ODAP (3-Ar-Oxalylamino-L-alanine I.-BOAA)... 

Acid amides have occasionally, like formamide, been used to produce 8-substituted purines. Acetamide and 2,4,5-triamino-6-oxo-l,6-dihydropyrimidine afforded 8-methyl-guanine (60JA2633) and 8-methyl- or ethyl-xanthines resulted from acetamide or propion-amide and 4,5-diamino-2,6-dioxo-l,2,3,6-tetrahydropyrimidine (53CB333). Diamides such... 

Although NCS is S bound in the solid state of trans-[Ir(pip)4(NCS)2]BPh4 (pip = piperidine), it is N bound initially in solution and in the solid state when NCS is the counter-ion. With both counter-ions prolonged aging of solutions yields the S-bound complex. The M—O bond is retained during the reaction of [Ir(NH3)50H] and propionic anhydride to give the propionate complex. Iridium(iii) complexes of 3,3 -diamino-4,4 -dihydroxy-diphenylsulphone and R X=NR (X = N or CH), IrHCl(N—C)(PR3)2, have been isolated. 

Verdini and coworkers [122] have introduced the 2-methyl-2-(2 -ni-tro)phenoxy-propionyl (Mnp) group for the preparation of stable monopro-tected gem-diamino alkyl residues 27 via IBTFA treatment of the carboxamide precursor 26. The precursor 26 is prepared by coupling amino a-carboxamide and 2-methyl-2-(2 -nitro)phenoxy-propionic acid as its O-succinimidyl ester 25. Hydrochloride salts, such as 27, are generally stable, crystalline compounds that can be stored at room temperature for several months. Once deprotonated, 27 is stable enough for acylation reactions (Scheme 9) [122]. 

Consumption of seeds of the genus Lathyrus (Fabaceae) by man and his domestic animals produces a syndrome called lathyrism. Different amino acids produce the two forms of this malady neurolathyrism and osteolathyrism. 3-Aminopropionitrile 0-aminopropionitrile) (59) is the active osteolathyritic factor in Lathyrus species. Several factors are responsible for neurolathyrism. 3-Cyanoalanine (58), its 4-glutamyl derivative, 2,4-diaminobutyric acid (56), and the N-oxalyl derivative of 2,3-diaminopropionic (a,3-diamino-propionic) acid (57) are all known to be involved. These compounds are found primarily in plants of the genus iMth-yrus. 3-Cyanoalanine (58) and its 4-glutamyl derivative are also common in Vida species. Several related series of compounds are found in other members of the Fabaceae. 

Lathyrinogenic amino acids nonproteogenic amino acids occurring in the seeds of some species of vetch (Lathyrus). They include diaminobutyric acid H2N-(CH2)2-CH(NH2)- 00H (neurolathrinogenic effect), p-aminopropionitrile, which occurs as the glutamyl peptide in the seeds of Lathyrus. odoratus, and presumably the N-oxaloyl-a,p-diamino-propionic acid HOOC-CH(NH2)CH2-NH-CO-COOH. The disease caused in humans and animals by L.a.a. is called lathyrism, and takes various forms, e.g. neuro-(nerve)- and osteo(bone)-lathyrism e.g. PiAiy-gluta-rayI)aminopropionitrile causes skeletal abnormalities in rats... 

A simple procedure for preparing 6-nitroimidazo[4,5-b]pyridine involves the action of formic acid on 2,3-diamino-5-nitropyridine. Similarly, when 3-amino-2-(0-diethylaminoethylamino)-S-nitropyridine (IX-210) is heated with formic acid (IX-211, R = H), the product is 3propionic acid (IX-211, R = Cj Hs), IX-212 (R = Cj Hj ) is obtained. ... 

Figure 43 (a) Third generation peptide dendrimer ((Ac-His-Lys)8(Dap-His-Lys)4(Dap-His-Lys)2Dap-His-Lys-NH2) (Dap, diamino propionic acid) (b) Possible mechanisms for ester hydrolysis. 

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