Propionaldehyde 2,2-dimethyl-3-

Hydrogen sulfide 3-(Methylthio)-propionaldehyde Dimethyl disulfide ... 

Regiospecific alkylation of dimethylhydrazone anions with the masked acrolein equivalent, 3-bromo-propionaldehyde dimethyl acetal, has brcn used as an alternative to a conventional Michael reaction in Corey s total synthesis of picrotoxinin (c/. equation 13). Azaallyllithium reagents derived from aldehyde and ketone hydrazones, unlike enolates, yield monoalkylation products with control of both regio-chemistry and stereochemistry. In appropriate cases, alkylation followed by deprotection to form a dicarbonyl product can be a very effective synthetic strategy. 

Chemicals responsible for odor in some PUR foams were synthesised by polymerisation of PO in CH2CI2 with Bp2(C2H )20 catalyst (114). The yield was 25% volatile material and 75% polymeric material. The 25% fraction consisted of dimethyldioxane isomers, dioxolane isomers, DPG, TPG, crown ethers, tetramers, pentamers, etc, and 2-ethy1-4,7-dimethyl-1,3,6-trioxacane (acetal of DPG and propionaldehyde). The latter compound is mainly responsible for the musty odor found in some PUR foams. This material is not formed under basic conditions but probably arises during the workup when acidic clays are used for catalyst removal. 

ETHYLENE GLYCOL ETHYL MERCAPTAN DIMETHYL SULPHIDE ETHYL AMINE DIMETHYL AMIDE MONOETHANOLAMINE ETHYLENEDIAMINE ACRYLONITRILE PROPADIENE METHYL ACETYLENE ACROLEIN ACRYLIC ACID VINYL FORMATE ALLYL CHLORIDE 1 2 3-TRICHLOROPROPANE PROPIONITRILE CYCLOPROPANE PROPYLENE 1 2-DICHLOROPROPANE ACETONE ALLYL ALCOHOL PROPIONALDEHYDE PROPYLENE OXIDE VINYL METHYL ETHER PROPIONIC ACID ETHYL FORMATE METHYL ACETATE PROPYL CHLORIDE ISOPROPYL CHLORIDE PROPANE... 

Durch Kondensation von Furfurol mit Propionaldehyd statt Acetaldehyd und uber die gleichen Abwandlungen wie im vorstehenden Schema erhielt Pommer 5-Methyl-azulen [67], 5,8-Dimethyl- [65] und 5-Methyl-8-Isopropyl-azulen [72], wahrend 5-Methylfurfurol und Propionaldehyd zum 1,5-Dimethyl- [21] und zum 1,5,8-Trimethylazulen [43] fiihrten. 

The most important sulfur heterocycles with a five-membered ring and three sulfur atoms are the diastereomeric 3,5-dialkyl-1,2,4-trithiolanes 6. The dimethyl derivatives (6, R - Me) have been found in various cooked foods, such as mushrooms (41), boiled beef (42) commercial beef extract (43), boiled antarctic krills (44), red algae (45), and several model systems containing a source of sulfur (2,19,29), The diethyl derivative (6, R - Et) was identified by Ledl (33) and by Sultan, with propionaldehyde as the starting material. The dipropyl and diisopropyl derivatives (6,... 

Similarly, with acetaldehyde and propionaldehyde as the starting materials, one gets the 2,4-dimethyl-6-ethyl- and 2-ethy 1-4,6-dimethyl derivatives (33,37), In the presence of acetaldehyde, the higher aldehydes give various substituted... 

Synthesis of racemic naproxene Friedel-Crafts acylation (aluminum chloride - nitrobenzene) of p-naphthol methyl ether affords 2-acetyl-6-methoxy naphthalene, which, when treated with either dimethyl sulfonium or dimethylsulfoxonium methylide, gives 2-(6-methoxynaphthalen-2-yl)propylene oxide. Treatment of the latter with boron trifluoride etherate in tetrahydrofuran gives 2-(6-methoxynaphthalen-2-yl)propionaldehyde, which is oxidized using Jones reagent (4 M chromic acid) to yield the racemic 2-(6-methoxynaphthalen-2-yl)propionic acid. 

The PPA-promoted cyclizations of (phenylthio)acetaldehyde dimethyl acetal and a-(phenylthio)propionaldehyde diethyl acetal yield benzo[6]thiophene together with 3-methoxy-2,3-dihydrobenzo-[6]thiophene, and a mixture of 2- and 3-methylbenzo[6]thiophene, respectively.296 Mechanisms have been proposed to account for these results. 

AW-Dimethyl-Ot-isocyanoacetamide 10 is the substrate of choice in the reaction with acetaldehyde (98.6% ee) or primary aldehydes such as propionaldehyde (96.3% ee) or isovaler-aldehyde (97.3% ee) (Scheme 8B1.5, Table 8B1.5) [19]. The oxazolinecarboxamides 11 thus prepared can be converted to P-hydroxy-a-amino acids by acidic hydrolysis. The aldol reaction... 

A mixture of 288 g (4 mols) of isobutyraldehyde, 288 g of methanol was cooled to 10°C and 170 g (2 mols) of 36.6% formalin containing 8.5 g (3% based on isobutyraldehyde) of sodium hydroxide was added dropwise over a 55 minute period to produce alpha,alpha-dimethyl-beta-hydroxy-propionaldehyde. The mixture was stirred for an additional 2 hours at 10-15°C and then contacted with acetic acid to neutralize the catalyst. The excess isobutyraldehyde and methanol were stripped off at a kettle temperature of 50°C at 25 mm. To the residual a,a-dimethyl-beta-hydroxypropionaldehyde a mixture of 260 ml of methanol and 2 g (0.75%) sodium cyanide was added and the solution cooled to 10°C before adding 59.4 g (2.2 mols) of hydrogen cyanide dropwise over a 35 minute period to produce a,y-dihydroxy-p,p-dimethylbutyronitrile. The mixture was stirred at 10°C for one hour period and then contacted with acetic acid to neutralize the catalyst before stripping off the excess methanol to a kettle temperature of 45°C at 18 mm. The crude cyanohydrin was then hydrolysed by heating with 4 mols of concentrated hydrochloric acid at 80°C for 2 hours, then diluting with an equal volume of water and heating at 100°C for an additional 8 hours. The aqueous mixture was extracted continuously with ethylene dichloride. The solvent was... 

A powerful oxidizer. Explosive reaction with acetaldehyde, acetic acid + heat, acetic anhydride + heat, benzaldehyde, benzene, benzylthylaniUne, butyraldehyde, 1,3-dimethylhexahydropyrimidone, diethyl ether, ethylacetate, isopropylacetate, methyl dioxane, pelargonic acid, pentyl acetate, phosphoms + heat, propionaldehyde, and other organic materials or solvents. Forms a friction- and heat-sensitive explosive mixture with potassium hexacyanoferrate. Ignites on contact with alcohols, acetic anhydride + tetrahydronaphthalene, acetone, butanol, chromium(II) sulfide, cyclohexanol, dimethyl formamide, ethanol, ethylene glycol, methanol, 2-propanol, pyridine. Violent reaction with acetic anhydride + 3-methylphenol (above 75°C), acetylene, bromine pentafluoride, glycerol, hexamethylphosphoramide, peroxyformic acid, selenium, sodium amide. Incandescent reaction with alkali metals (e.g., sodium, potassium), ammonia, arsenic, butyric acid (above 100°C), chlorine trifluoride, hydrogen sulfide + heat, sodium + heat, and sulfur. Incompatible with N,N-dimethylformamide. 

Because of the commercial importance of fosfomycin, it is not surprising that several important and attractive synthetic methods are reported in patents. They include, for example, precursors such as dimethyl hydroxymethylphosphonate, dimethyl, dibenzyl, and diallyl formylphosphonate, trimethyl phosphite and 2-cyano-1-hydroxypropene, 9 trialkyl phosphite and 2-chloro-propionaldehyde or 2-acetoxypropionaldehydc, diethyl chloromethylphosphonate, dibenzyl phosphite, and 1-chloro-1,2-propylene oxide,2 propynylphosphonic acid, propenylphos-phonic acid,2 2-chloro-(czT-l,2-epoxypropyl)phosphonic acid, and extrusion reactions on thermolysis. The resolution of racemic acids has also been reported. In search of new effective antibiotics, a large variety of substituted epoxyethylphosphonic acids have been pre-pared.249... 

The main by-products formed are carbon dioxide, alcohols (ethanol, butanol, etc.) aldehydes (propionaldehyde, n- and isobutyraldehydes), acids (formic, propionic etc.), esters (methyl formate and acetate), and ethers (dimethyl ether, etc.). Some of them, obtained in large quantifies (methyl acetate and dimethyl ether), can be recycled. 

During the purification step, especially in the purification of polyethers with adsorbents (for example with aluminium silicates) a specific odour appears due to a cyclic compound, which was identified as cyclic acetal of dipropyleneglycol with propionaldehyde (2-ethyl-4,7-dimethyl-1,3,6-trioxacane) (Figure 4.35). 

The aldehydes and ketones most commonly used are benzaldehyde, acetaldehyde, formaldehyde, and acetone. However, -butyraldehyde, n-propionaldehyde, salicylaldehyde, p-tolualdehyde, and 2-furaldehyde have also been employed. A number of unsaturated aldehydes, for example, 3,7-dimethyl-2,6-octadienal (citral) and cinnamaldehyde, have yielded cyclic acetals. Acetals have been prepared from 2-butanone, cyclohexanone, and glyoxal. ... 

Dimethyl-3-hydroxypropanal EINECS 209-895-4 HSDB 5711 Hydracrylaldehyde, 2,2-dimethyl 3-Hydroxy-2,2-dimethyl-propionaldehyde 3-Hydroxy-2,2-dimethylpropanai ... 

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