Propionaldehyde 2-chloro

A mixture of 2.9 grams of 5-chloro-2,4-disulfamvl-aniline in 20 ml of anhydrous diethylene-glycol dimethylether, 0.44 gram of propionaldehyde and 0.5 ml of a solution of hydrogen chloride in ethyl acetate (109.5 grams hydrogen chloride per 1,000 ml) Is heated to 80° to 90°C and maintained at that temperature for 1 hour. The reaction mixture is concentrated under reduced pressure on addition of water, the product separates and is then recrystal-lized from ethanol or aqueous ethanol to yield the desired 6-chloro-3-ethvl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide, MP 269° to 270°C. 

In similar electrochlorination experiments, propionaldehyde [86], ethylene [87], tetramethylpiperidine derivatives [88], amines [89], acetone [90], and polymers [91] have been converted into chloro derivatives. Mechanistic studies have aimed at elucidating the role of chloronium intermediates [92], water [93], and of redox mediators such as Ce +[94] in the electrochlorination process. 

A mixture of 2.9 grams of 5-chloro-2,4-disulfamyl-aniline in 20 ml of anhydrous diethylene glycoldimethylether, 0.44 gram of propionaldehyde and... 

This reaction is applicable to higher aldehydes and primary or secondary alcohols. Thus, paraldehyde and alcohols combine to give a-chloro-ethyl alkyl ethers (93-99%). Similarly, propionaldehyde and n-butyr-aldehyde yield a-chloro-n-propyl and a-chloro- -butyl alkyl ethers, respectively. ... 

Because of the commercial importance of fosfomycin, it is not surprising that several important and attractive synthetic methods are reported in patents. They include, for example, precursors such as dimethyl hydroxymethylphosphonate, dimethyl, dibenzyl, and diallyl formylphosphonate, trimethyl phosphite and 2-cyano-1-hydroxypropene, 9 trialkyl phosphite and 2-chloro-propionaldehyde or 2-acetoxypropionaldehydc, diethyl chloromethylphosphonate, dibenzyl phosphite, and 1-chloro-1,2-propylene oxide,2 propynylphosphonic acid, propenylphos-phonic acid,2 2-chloro-(czT-l,2-epoxypropyl)phosphonic acid, and extrusion reactions on thermolysis. The resolution of racemic acids has also been reported. In search of new effective antibiotics, a large variety of substituted epoxyethylphosphonic acids have been pre-pared.249... 

Chloramine-T, the sodium salt of A-chloro-p-tolucncsulfonamidc, tosylami-nates a number of in situ generated enamines of a-substituted propionaldehydes (see Eq. 78), a-substituted arylacetaldehydes, and methyl arylmethyl ketones.78... 

Studies in this area were reported as early as 1949 by Lederle chemists [243], who used the Waller synthesis (2,4,5,6-tetraaminopyrimidine, 2,3-dibromo-propionaldehyde and an Af-(4-aminobenzoyl)-a-amino acid or ester) to prepare the alanine, valine, isoleucine, serine, threonine, phenylalanine and tryptophan analogues (VIII.1)-(VIII.7), respectively. Compounds (VIII.2) and (VIII.3) were also treated with CI2 in AcOH to obtain the 3 -chloro derivatives (VIII,8) and (VIII.9). Although the data reported were very scanty, consisting only of activity ratios relative to 10-methylfolic acid in the S.faecium microbioassay, replacement of the glutamate moiety by a-amino monoacids was clearly shown to be an unpromising route to potent antifolates. 

In chlorination of aldehydes the nature of the product (a-chloro aldehyde or carboxylic acid) depends both on the concentration of the added acid and on the nature of its anion 628 In 0.5N-hydrochloric acid at 10-15° chlorination of propionaldehyde gives 98% of propionic acid but in 4.5-6.3N-hydrochloric acid gives 90-92% of 2-chloropropionaldehyde. The concentration of acid is held constant by addition of water during the chlorination. 

Methyl-2-)methylthio) propionaldehyde 0-(methylcarbamoyl)oxime. 2-Chloro-4-ethylamino-6-isopropylamino-S-triazine. 

Chloro-l-pentyne Propionaldehyde 8-Chloro-trans-4-octen-3-ol 47... 

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