Trichloro-2-methyl-2-propanol

The activity spectrum of l,l,l-trichloro-methyl-2-propanol comprises bacteria and fungi. It may be used as a preservative for cosmetic and pharmaceutical products. In the EC list of preservatives which cosmetic products may contain it is mentioned under the name Chlorobutanolum . The authorized concentration is 0,5% excluded is the application in sprays. Printed label warning Contains chlorobutanol. - Percentage of use in US cosmetic formulations 0.005%. 

The para and ortho positions of phenols condense at the carbonyl group of acetone to make bisphenols, eg, bisphenol A, 4,4 -(l-methylethyhdene)bisphenol [80-05-07]). If the H atom is activated, CICH— compounds add to the carbonyl group in the presence of strong base chloroform gives chloretone (l,l,l-trichloro-2-methyl-2-propanol [57-15-8]). 

In the presence of an alkali metal hydroxide at about 50°C, chloroform condenses with acetone to give l,l,l-trichloro-2-methyl-2-propanol, [57-15-8] ie, chlorobutanol, chloretone, or acetone—chloroform (9,10). Chlorobutanol is a white crystalline substance with a campborlike odor its sedative, anesthetic, and antiseptic properties have given the compound some importance in the pharmaceutical industry. 

Sasson and Rempel [97] showed that the system [(PPh3)3RuCl2]/secondary alcohol is suitable for the selective transformation of 1,1,1,3-tetrachloro into 1,1,3-trichloro compounds. Similarly, Blum and coworkers [98, 99] employed [(PPh3)3RuCl2] as well as polystyrene-anchored Rh, Ru and Ir complexes for the hydrogen transfer from alcohols to trihalomethyl compounds, leading to dihalo-methyl derivatives. For example, one of the Cl atoms of 2,2,2-trichloro-l-phenyl-ethanol was displaced by H at 140-160 °C in 2-propanol. The polymer-anchored catalysts proved to be resistant to leaching [99]. 

Propanone reacts with trichloromethane in the presence of potassium hydroxide to give 1,1,1-trichloro-2-methyl-2-propanol. What is likely to be the mechanism of this reaction What further evidence could be gained to establish the mechanism (If you do not see a possible answer, refer to Section 14-7B for helpful information.)... 

The electroreduction of l,l,l-trichloro-2-hydroxy-4-methyl-4-pentene (123) at a lead cathode led to two products, l,l-dichloro-4-methyl-2,4-pentadiene (124) and 1,1-dichloro-2-hydroxy-4-methyl-4-pentene (125) (equation 64). Compound 124 was favored (yields > 75%) in acidic medium using methanol or 2-propanol as solvent97. 

Conversely, the decrease in the rate constant for the hydroxide ion catalyzed reaction of l,l,l-trichloro-2-methyl-2-propanol in the presence of polyoxyethylene(23) dodecanol and polyoxyethylene sorbitan mono-decanoate has been rationalized by assuming that the nucleophilic reaction occurs only in the bulk solution and that a substantial fraction of the substrate is solubilized by the surfactant. The latter assumption was verified by measurements of the solubility of l,l,l-trichloro-2-methyl-2-propanol, and hence the distribution coefficients, in the micellar systems (Anderson and Slade, 1966). 

P,P,P-TRICHLORO-tert-BUTYL ALCOHOL 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL... 

The cyclocondensation of 4-alkoxy-l,l,l-trichloro-3-alken-2-ones with hydroxyl-amine using toluene as solvent is more efficient under the action of microwave irradiation than using the classical method (the average time ratio for the two methods is 1 160) [49]. Katritzky et al. have demonstrated the applicability of microwaves to the synthesis of a variety of 2-oxazolines from readily available N-acylbenzotriazoles and 2-amino-2-methyl-l-propanol under mild conditions (80 °C) with short reaction times (12 min). Use of N-acyl benzotriazoles also avoids some complications in microwave reactions, for example dimerization or the exclusive formation of amides from carboxylic acids [50]. 

Chlorobutanol hemihydrate CAS 6001-64-5 EINECS/ELINCS 200-317-6 Synonyms Acetone chloroform p,p,p-Trichloro-t-butyl alcohol 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate Empirical C4H7CI3O Y2H20 Formula Cl3CC(CH3)20H Y2H2O Properties M.w. 186.46 Uses Antimicrobial, preservative for pharmaceuticals... 

Chlorobutanol n (chlorbutanol, l,l,l-trichloro-2-methyl-2-propanol, acetone chloroform, trichloro-tert-butyl alcohol) Cl3CC(CH3)20H. A plasticizer for esters and ethers of cellulose. 

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