Propane, 2,2-dimethyl-l-phenyl

Propane, 2,2-dimethyl-l-phenyl-, 55, 112 Propane, 2 isocyano 2 methyl-, 55, 96 Propanenitrile, 2-(2-butylthioethenyl) 2,3, 3-tnphenyl- [Propiomtnle, 2-(2-butyl thiovinyl)-2,3,3-tnphenyl-[, 55, 102 Propanenitrile, 2-mellioxy inefhyl-2-phenyl-[Propiomtrile, 2-methoxymethyl-2-phenyl-], 55, 94... 

Penten-l-in 5-Cyclohexyl-V/ld, 669 Propan 2,2-Dimethyl-l-phenyl-V/la, 479, 492, 496 Spiro 2,4 hepta-4,6-dien, 1,2-Diethyl-E19b, 797 (Carben + En) Tetracyclo 4.2.0.02,8.04, octan 1.5,5-Trimethyl- E19b, 438 (a-Eliminierung//Mnsertion) Tetracyclo[3.2.1.02-7.03,6 octan ... 

Propane, l-bromo-3-chloro-2,2-dimethoxy-[22089-54-9],57,41 Propane, l-bromo-2,2-dimethyl- [630-17-1], 58, 143, 144, 146 Propane, 2,2-dimethyl-l-phenyl-, 55, 112 Propane, l-fluoro-2-methyl- [359-00-2],... 

L-Proline, tert-butyloxycar-bonyl-, 53, 25 Propanal, 2,2-dimethyl-3-phenyl-, 54, 46... 

Das durch alkalischen RingschluB von l-Benzylimino-3-chlor-2,2-dimethyl-l-phenyl-(bzw. 4-methyl-phenyl)-propan erhaltene 1-Aryl-1-benzylidenamino-2,2-dimethyl-cyclo-propan wird sauer zu 1-Amino-2,2-dimethyl-1-phenyl (bzw. 4-metkyl-pkenyl)-cyclopropan hydrolysiert3. 

Propan 2.2-Dimethyl-l-lithio-l-(2-lithio-phenyl-imino)- EI9d,... 

Indol 3-(2-Dimethylamino-ethyl)-5-hydroxy- IV/lb, 803 Malonsaure (3-Oxo-3,4,4-trimethyl-cyclohexyl)- -dinitril E5, 1518 I(NC)2CH2 + 3-Oxo—1-en] Propan 2,2-Dimethyl-l-(2-methyl-phenyl)-l-nitrosimino- E14b, 746 (N-Nitrosier.)... 

Dimethyl-3-phenyl- 1-propanol is produced in two steps. Alkylation of isobutyr-aldehyde with benzyl chloride leads to 2,2-dimethyl-3-phenyl-l-propanal which is subsequently reduced to the alcohol [142a]. 

Cyclic Disulphides and Cyclic Diselenides.—Formation. No fundamentally new methods of synthesis of this class of compounds have been reported in the past two years. For l,2>dithiolan the oxidation of l,3>dithiols remains a favoured method, the use of iodine in the presence of triethylamine leading smoothly to 1,2-dithiolans without attendant polymerization. cis- and tra/ -l,2-Dithiolan-3,5-dicarboxylic acids were prepared from a diastereo-isomeric mixture of dimethyl 2,4-dibromoglutarates by sequential treatment with potassium thioacetate and potassium hydroxide in the presence of iodine,and jyn-2,3-dithiabicyclo[3,2,l]octan-8-ol was formed from 2,6-dibromocyclohexanone by successive treatment with potassium thiocyanate, lithium aluminium hydride, and iodine. The stereoselective formation of the less thermodynamically stable alcohol in this case was attributed partly to the formation of chelates with sulphur-aluminium bonds. 2,2-Dimethyl-l,3-dibromopropane was converted into 4,4-dimethyl-l,2-diselenolan on treatment with potassium selenocyanate at 175 °C, but at 140 °C the product was 3,3-dimethylselenetan. Reductive debenzylation of 2-alkylamino-l,3-bis(benzylthio)propanes with lithium in liquid ammonia and oxidation of the resultant dithiols with air afforded 4-dialkylamino-l,2-dithiolans, whilst treatment of a-bromomethyl-chalcone with sodium hydrosulphide gave, as minor product, trans-3 phenyl-4-benzoyl-l,2-dithiolan. Among the many products of thermal decomposition of /ra/ -2,4-diphenylthietan was l,4,5,7-tetraphenyl-2,3-dithiabicyclo [2,2,2]octane. ... 

C. (E)-3,3-Dimethyl-l-phenyl-1 -butene. In a 1-L, two-necked, round-bottomed flask fitted with a reflux condenser, rubber septum, and a magnetic stirring bar are placed 17.8 g (0.08 mol) of 2-methyl-2-(2-phenylethenyl)-1,3-dithiolane and 2.17 g (0.004 mol) of [1,3-bis(diphenylphosphino)propane]nickel(ll) chloride [NiCl2(dppp)] (Note 5). The flask is evacuated and flushed with nitrogen three times. To the above mixture is added 300 mL of anhydrous tetrahydrofuran (Note 6). The ether solution of methylmagnesium iodide prepared in Step B is introduced with a double-ended needle in one portion (Note 7). The mixture is heated under reflux for 24 hr, cooled to room temperature, and treated with 200 mL of saturated ammonium chloride solution. 

When a metal ion such as nickel (II) is absent, thiazoles and mercaptals are formed. Such reactions have been carried out in which the diketone was biacetyl, 2,3-pentanedione, 2,3-octanedione, l-phenyl-l,2-propane-dione, and 1,2-cyclohexanedione (51). In like manner, the tris complexes of W,W -dimethyl-2,3-butane diimine with iron(II), cobalt(II), and nickel(II) may be prepared from methylamine and biacetyl when the appropriate metal ion (27j 28j 41) is present. Replacing methylamine with hydroxylamine causes the formation of a-dioximes (13). 

Ausnahmen sind die Synthesen des 4-Diisopropylamino-2,3-dimethyl-1 -phenyl-5-py-razolon aus Aceton und 4-Amino-2,3-dimethyl-l-phenyl-5-pyrazolon14 und die von N,N-Dialkyl-anilinen durch reduktive Aminierung von Alkanonen in Form ihrer Acetale mit Anilinen13 (vgl. S. 452). So erhalt man z.B. N,N-Diisopropyl-anilin aus 2,2-Dimethoxy-propan und Anilin iiber Palladium/Kohle (5%) (120 bar/50°) zu 56% d.Th. Mit zunehmender Kettenlange der Acetale sind die Reaktionsbedingungen auf 135-155° und 100 bar zu steigern15. 

An analogous stereochemical outcome was observed when the ethylation of racemic 2-phenyl-propanal was catalyzed by (-)-(/ )-l-(diisopropylamino)-3,3-dimethyl-2-butanol36. The reaction was run to 70% conversion and again the ratio of syn- to anff-diastercomers was 3 1. In this case, however, the 7 -configurated aldehyde was predominantly consumed and both enantiomers of the aldehyde were predominantly alkylated from the Re-side. The optical purity of the unreacted (S)-2-phenylpropanal was 85.7% ee. 

Zur Aminomcthylierung von symmetrischen Dialkyl-ketonen (z. B. Cycloalkanonen) und von Ketonen mit nur einer substituierbarcn a-Stellung eignet sich ein einfaches Verfahren, bei welchem das Keton zunachst mit Kalium-hydrid in Tetrahydrofuran behandelt und danach mit N,N-Dimethyl-methaniminium-iodid umgesetzt wird. Man erhalt auf diese Weisez.B. 2- (Dimethylamino-methyl)-l-oxo-cyclohexan (88%) und 3-Dimethylamino-2-methyl-1-oxo-1 -phenyl-propan (75%)2. 

Das ans Benzyl-dimethyl-(2-oxo-2-phenyl-ethyl)-ammonium-broniid durch Dehydrobro-mierung mittels Natronlauge erhaltliche N-Ylid kann, nach Isolierung in wasserfreier Form, thermisch in fast quantitativer Ausbeute zu 2-Dimethylamino-l,3-diphenyl-l-oxo-propan (X = H R = CgH,) umgelagert werden2. 

D i(3-nitro-5-methyl-4-hydroxyphenyl) -dimethyl methane or Di(nitfomethyl-hydroxy-phenyl) -propane. See 2,2-Bis(3-nitro-5-nethyl-4-hydroxyphenyl) propane in Vol 2, p B152-L... 

Six more polyaryl ethers were made from 2,6-dichlorobenzonitrile (2) and one of the following monomers l,l -bis(4-hydroxy-3,5-dimethyl phenyl) cyclohexane 2,2 -bis (4-hydroxyphenyl) -2-phenyl ethane 1,3-bis(4-hydroxyphenyl)-1-ethyl cyclohexane 2- ( hydroxyphenyl)-2-[3-(4-hydroxyphenyl) -4-methyl cyclohexyl ] propane 2,2 -bis (4-hydroxy-3,5-dimethyl phenyl) propane and bisphenol A. 

Propan 2-Chlor-2-(3,5-dimethyl-4-hydroxy-phenyl)-l, 1,1,3,3,3-hexafluor- VII/3b, 426... 

Phenol 3-(bzw. 4)-Methyl-2-pyrrolidino- VI/lc, 910 Piperidin l-[2(bzw. 4)-Hydroxy-phenyl]- E16d, 656 [Dialkylami-nierung (Minisci-Reaktion)] Propan m . .ro-l-(3,4-Dimethyl-phenyl)-2-nitroso- E16a, 968 (NH2 - NO)... 

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