Prolactin promoter

Prolactin inhibitors. Dopamine released from hypothalamic neurosecretory nerve cells inhibits the secretion of prolactin from the adenohypophysis (p. 238). Prolactin promotes production of breast milk during the lactation period moreover it inhibits the secretion of gonadorelin. D2 receptor agonists prevent prolactin secretion and can be used for weaning and the treatment of fe-... 

Takasuka N, White MRH, Wood CD, Robertson WR, Davis JRE. Dynamic changes in prolactin promoter activation in individual living lactotrophic cells. Endocrinol 1998 139 1361-8. 

Normal prenatal and postnatal ovarian development, with multiple nonovulatory hemorrhagic follicles as an adult, 30-40% incidence of ovarian cancer in 18 months Normal prenatal development, but insensitive to the development promoted by estrogens during puberty. Sensitive to progesterone and prolactin. 

Whale, R., Quested, D.J., Laver, D., Harrison, P.J., and Cowen, P.J. (2000). Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine. Psychopharmacology (Berl) 150 120—122. 

Serotonin 2A antagonism may reverse dopamine 2 antagonism in the tuberoinfundibular pathway. There is an antagonistic and reciprocal relationship between serotonin and dopamine in the control of prolactin secretion from the pituitary lactoroph cells. That is, dopamine inhibits prolactin release by stimulating D2 receptors (Fig. 11—30), whereas serotonin promotes prolactin release by stimulating 5HT2A receptors (Fig. 11—31). 

Acutely methyldopa promotes the release of growth hormone and prolactin, but the long-term significance of this is unclear. However, there have been reports of... 

Lin S, Arai AC, Espana RA, Berridge CW, Leslie FM, Huguenard JR, Vergnes M, Civelli O. Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures. Neuroscience 2002 114 229-238. 

Obal Jr F, Payne L, Kacsoh B, Opp M, Kapas L, Grosvenor CE, Krueger JM.. Involvement of prolactin in the REM sleep-promoting activity of systemic vasoactive intestinal peptide (VIP). Brain Res 1994 645 143-149. 

Zhang SQ, Inoue S, Kimura M. Sleep-promoting activity of prolactin-releasing peptide (PrRP) in the rat. Neuroreport 2001 12 3173-3176. 

Both in vitro and in vivo tests have shown that some of the eicosanoids affect the secretion of anterior pituitary hormones. PGE compounds promote the release of growth hormone, prolactin, TSH, ACTH, FSH, and LH. However, endocrine changes reflecting significant release of these hormones have not been reported in patients receiving PGE compounds. LTC4 and LTD4 stimulate LHRH and LH secretion (see below). 

Expression of the cDNA for the rabbit GH receptor and of the extracellular domain of the human receptor was obtained in transfected monkey COS-7 cells. The proteins so obtained bound 125I-labelled human GH, and showed a specificity similar to that of the receptors obtained from normal tissues. Thus, the rabbit receptor could bind human GH, bovine GH and to a lesser extent ovine prolactin, while the human receptor bound human GH but not bovine GH or ovine prolactin. This provides strong evidence that these receptors mediate the growth-promoting actions of GH, since biological responses show a similar specificity. 

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