Progenitor sustained

NT3 plays an earlier role in development than other neurotrophin family members. It sustains progenitor cells of the neural crest, which then give rise to sympathetic and sensory ganglia, as well as a number of other... 

Third type of culture is stroma-non contact . In this system primitive progenitor cells are sustained when cells are co-cultured with irradiated allogeneic stroma but separated from it by the 0,4 micron membrane in transwell inserts (Costar, Cambridge, MA). These cultures are maintained by daily supplementation of stromal feeder conditioned media (Roller et al. 1998, Verfaillie, 2001) successfiilly expanded umbilical cord blood cells in a novel automated perfusion culture system. Development these approaches followed in the studies of investigators who incorporated the stromal components into the expansion culture. Recently published trials by McNiece et al. 2000 are more encouraging where cells were expanded in static culture for 10 days in Teflon bags (American Fluoroseal, USA). 

The quality demands for product performance constitute a significant hurdle to market adoption of these new raw materials. The market has so far demonstrated that interest in adoption of cost-effective products with renewable content is sustainable as long as product performance is not compromised. The different chemistries that have been harnessed to pursue this opportunity are stiU in an evolutionary stage, as polyol producers respond to market pressures for the high quality and low price that has previously fuelled the success of the petrochemical progenitors. Time will tell which, if any, of the approaches to replacement of petroleum with renewable hydrocarbons will sustain a market presence, and will succeed at impacting the consumption of global petrochemical stocks. 

Sustained Progenitor Cell Existence in Germinative Zones... 

Robinson S N, Chavez J M, Blonder J M, et al. (2005). Hematopoietic progenitor cell mobilization in mice by sustained delivery of granulocyte colony-stimulating factor. J. Interferon Cytokine Res. 25 490-500. 

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