Profiles of leads

In summary, such simple classification schemes for drug-likeness can, in a very fast and robust manner, help to enrich compound selections with drug-like molecules. These filters are very general and cannot be interpreted any further. Thus, they are seen rather as a complement to the more in-depth profiling of leads and drugs by using molecular properties and identifying trends in compound series. 

Figure 12. Ion microprobe depth profiles of lead and thallium in coal fly ash taken before (unextracted) and after solvent leaching with H2O or DMSO...

The Market Research and Trends Tool opens an in-depth analysis of an industry, its trends and technologies. Explore sector-by-sector analysis. Go deeper for specific profiles of leading companies in each industry. 

Figure 6 Alternative approaches to the drug-discovery process. Upper panel Sequential process with profiling of the final-development candidates only. Lower Panel Parallel process including early profiling of lead candidates before starting the optimization and final-development candidates as well...

Figure 41. Voltammograms for stripping of lead adsorbed on gold faces the co s of which are on (a) the (lll)>(no) zone (b) the (111)-(311) section of the (Ill)-(IOO) zone (c) the (311)-(100) section of the (Ill)-(IOO) zone (d) the (100)-(210) section of the (lOO)-(llO) zone and (e) the (210)-(110) section of the (lOO)-(llO) zone. Sweep rate = 20 mV s 10 mM HCIO4 + 1 mAf Pbp2 solutions deaerated with nitrogen and stirred. Although the UPD of oxygen was also included in each cycle, this is not shown on the figure because it occurs at more positive potentials. Deposition and stripping profiles of lead are similar for nearly all faces.

Answer E. The profile of lead toxicity includes decreased heme synthesis, anemia, nephropathy, and peripheral neuropathy, the last leading to foot drop or wrist drop. Garlic breath and watery stools are associated with arsenic poisoning. Chronic gingivitis and loose teeth are features of mercury poisoning. 

Lead inputs to oceanic systems have been measured8. Using isotope correlation, they identified the prime aerosol source as leaded gasoline. Profiles of lead concentrations in ocean water cluster between 0.02 pg/1 and 0.04 pg/1 for water below 500 m shallow water coastal concentrations may range from 0.07 to 0.35 pg Pb/19. While values as high as 10 jug Pb/1 have been reported, it is possible that some of these higher values reflect shipboard contamination9. ... 

In detail, most of the concentration profiles reveal increasing values from the bottom of the core up to a depth of 100 cm, reaching a first maximum there. Subsequently, the values decrease to a fairly constant level at a depth between 80 cm and 30 cm. The averaged values in this zone are Cd 6 pg/g, Ni 50 pg/g, Cr 85 pg/g, Cu 180 pg/g, Pb 240 pg/g and Zn 1100 pg/g. A second concentration maximum was observed at a depth of approx. 25 cm. In the top layers of the sediment core the concentrations decrease down to values similar to those in the 30-80 cm zone. These trends are best developed in the concentration profiles of lead, copper, zinc and cadmium (Fig. 4). 

Ans E The profile of lead toxicity includes decreased heme synthesis, ane-... 

Flegal AR and Patterson CC (1983) Vertical concentration profiles of lead in the Central Pacific at 15N and 20S. Earth and Planetary Science Letters 64 19-32. 

Figure 4. Ellipsometrically determined profile of leading edge of squalane film spreading up vertical steel plate...

Flegal A.R., Itoh K., Patterson C.C. and Wong C.S., 1986, Vertical profile of lead isotopic compositions in the north-east Pacific. Nature, 321, 689-690. 

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