Product design bioavailability

Piehl DH (1973) Basic study - smoke balance and control. Available from http // tobaccodocuments.org/product.design/500997469-7475.html. Accessed 2 April 2007 Reininghaus W (1994) Bioavailability of nicotine. Available from http //ltdlimages.library. 

Stmcture-property relationships are central to food materials science and product design, since food microstmcture determines to a large extent many desirable characteristics of what we eat. Our expectations have gone far beyond the basic properties of eating quality and microbiological safety. We want to know how our food was produced and where. Consumers concerns about health and well-being demand that some nutrients are bioavailable after absorption in the gut. Last, but not least, we want to derive pleasure from gourmet quality foods. 

For IDA, IV iron, though costly, has superior bioavailability compared with oral preparations. In select individuals the bioavailability advantage of parenteral iron over oral iron can be the difference in the achievement of a successful outcome. The benefits of using combination oral iron products designed to enhance absorption is probably not warranted. 

N. A. Peppas, Mathematical modelling of diffusion processes in drug delivery systems in Controlled Drug Bioavailability, Wiley, Vol. 1, Drug Product Design and Performance, V.F. Smolen, L.A. Ball, (Eds), 203, New York (1984). 

Biopharmaceutical issues to be addressed will include a discussion of the pharmaceutical development process as it relates to in vivo and in vitro performance and the general approach taken concerning bioavailability, bioequivalence, and in vitro dissolution profiles. There should be a comparative analysis of relevant studies—objectives, study design, conduct, outcome, and data analyses. The effects of formulation changes (including different strengths of product and... 

The design of crystallization processes for the manufacture of Active Pharmaceutical Ingredients is a significant technical challenge to Process Research and Development groups throughout the Pharmaceutical and related industries. It requires an understanding of both the thermodynamic and kinetic aspects of crystallization, to ensure that the physical properties of the product will consistently meet specification. Failure to address these issues may lead to production problems associated with crystal size, shape and solubility, and to dissolution and bioavailability effects in the formulated product. 

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