Processed blend ingredients

Ensuring homogeneous mixing of the components (APIs and excipients) of a pharmaceutical preparation is a crucial prerequisite for obtaining proper solid dosages (tablets and capsules). Pharmaceutical manufacturers invest much time, labor and material resources in this process. Blending is intended to ensure uniform distribution of all components in the end products,so that each dose wiU contain the correct amount of the active ingredient. 

There remains the unanswered requirement to demonstrate blend uniformity of active ingredients B2. This issue might be addressed by testing the blends of a series of batches until sufficient data are accumulated to consider the process reliable. Hwang et al. have provided some insight into establishing an in-process blend test [15]. The vali-... 

Although the scientific principles behind this simple example of practical technology are easily understood, it illustrates the benefits that can be realized by considering the blending process as a dispersion operalion that may be followed, if necessary, by an operation to retard the rate at which the ingredients of the blend demix. In special cases, of course, the latter operalion may be rendered unnecessary by the selection of blend ingredients that are miscible in the first instance. 

Direct compression is a simple and time-saving process. The ingredients are blended and then compressed into the final tablet. The problem is that not all substances can be compressed directly, necessitating an intermediate granulation step. 

Process Blend all ingredients except the filler with the PVA. When eomplete add the filler slowly, blending well between additions. 

There are different manufacturing processes for the production of nanostructured polymeric blends. Peponi et al. reviewed [16] bottom-up and top-down processes for nanostructured polymers and advanced polymeric-based nanocomposites. Nanostrac-tured thermoplastics blends are reported under bottom-up matrix nanocomposites whereas nanostructured thermoplastic nanocomposites are introduced under top-down approaches. Polymer nanotechnologies are characterized by top-down processes including ingredients such as polymer and nanoparticles. They are introduced... 

Supplement Industry Qualitative and Quantitative Analysis of Ingredients, Process Blends, and Final Products... 

Initial evaluations of chemicals produced for screening are performed by smelling them from paper blotters. However, more information is necessary given the time and expense required to commercialize a new chemical. No matter how pleasant or desirable a potential odorant appears to be, its performance must be studied and compared with available ingredients in experimental fragrances. A material may fail to Hve up to the promise of its initial odor evaluation for a number of reasons. It is not at all uncommon to have a chemical disappear in a formulation or skew the overall odor in an undesirable way. Some materials are found to be hard to work with in that their odors stick out and caimot be blended weU. Because perfumery is an individuaHstic art, it is important to have more than one perfumer work with a material of interest and to have it tried in several different fragrance types. Aroma chemicals must be stable in use if their desirable odor properties are to reach the consumer. Therefore, testing in functional product appHcations is an important part of the evaluation process. Other properties that can be important for new aroma chemicals are substantivity on skin and cloth, and the abiHty to mask certain malodors. 

Manufacturing, analytical, and quaUty control procedures are thus estabhshed. Specifications for taw and in-process materials, as well as for final products per USP/NF and in-house standards are also determined. Process and formula vaUdation assures that each technological procedure in manufacture accomplishes its purpose most efficiently, eg, blending times for powdered mixtures in tableting, and that each formula ingredient is present in optimal concentrations (12). Thus, it serves to ensure process control (qv), reproducibiUty, and content uniformity. 

Direct Compression. This process is relatively simple and time saving. AH the ingredients are blended and then compressed into the final tablet. This is an excellent method, but encumbered by a number of problems. Not all substances can be compressed directly, necessitating a granulation step. Likewise, the flow properties of many blends of fine, particle-sized powders are not such as to ensure even filling of the die cavities of tablet presses. In addition, air entrapment can occur. 

Fig. 3. Schematic process flow diagram for an imitation cheese product having the following formulation dry ingredients, calcium caseinate (or rennet casein), 24.5 wt % tapioca flour, 3.0 wt % salt, 2.16 wt % adipic acid, 0.6 wt % vitamins and minerals, 0.1 wt % sorbic acid (mold inhibitor), 0.5 wt % fat—color blend, soybean oil hydrogenated to a Wiley melting point of 36°C, 21.3 wt % lactylated monoglycerides, 0.05 wt % red-orange coloring, 0.01 wt...

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