Probiotics antibody responses

An increased production of virus-neutralizing antibodies has also been shown in subjects treated with a polio vaccine in another pediatric application it was shown that, compared to controls, probiotic supplementation improved antibody responses in subjects receiving a single monovalent dose but not those who received three monovalent doses. 

Boge T, Remigy M, Vaudaine S, Tanguy J, Bourdet-Sicard R, van der Werf S. A probiotic fermented dairy drink improves antibody response to influenza vacdnation in the elderly in two randomised controlled trials. Vaccine. 2009 27 5677—5684. 

Soh SE, Ong DQ, Gerez I, et al. Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination. Vaccine. 2010 282577—2579. 

A critical criterion of selection is that the probiotic strain must be tolerated by the immune system and should not provoke the formation of antibodies against the probiotic. This latter property, in conjunction with the ability of some LAB to survive and colonize in the gut, has given rise to further applications, which involve their use as live vectors for oral immunization, i.e., introducing antigens targeting the GALT and aiming to induce a mucosal immune response (Marteau and Rambaud, 1993). 

The available data suggest that the capacity to boost the production of IL-10 differs considerably in response to different probiotic strains and also that the growth phase of orally administered individual Lactobacillus strains is linked to a differential expression of antigen-specific antibody subclasses IgGl and IgG2a. ... 

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