Processing Principle Investigators

John Newman, Ph.D., Professor of Chemical Engineering, University of California, Berkeley Principle Investigator, Inorganic Materials Research Division, Lawrence Berkeley Laboratory (Section 22, Alternative Separation Processes)... 

The Study Director is the pivotal person in any GLP study. The sponsor initiates the study and assigns a Study Director to act as the primary control point for all aspects of the study. The Processing Principle Investigator (PPI) acts as an agent of the Study Director and handles the processing phase of the study. The PPI reports directly to the Study Director, and quality assurance (QA) documents resulting from the processing phase are sent to the Study Director for approval. The Study Director has final say in all questions of compliance with GLP and interpretations of the protocol. The... 

System theory can be applied to incident investigation, reliability problems, quality problems, and other business losses. One of several reasons why system theory has received broad recognition relative to incident investigation is that it builds directly on current, verified process safety principles. In process safety, as in all other systems used to control risk to a business, there are three basic keys to controlling the risk (see Figure 3-4) ... 

In the Irradiation Processing Department the Analytical physics work has been carried out in the Design Analysis Unit tinder D. L. Condotta in the Operational Physics Subsection under G. C. Fullmer and in the Reactor Physics Unit under R. Nllson. Principle investigators have been D. B. Sing son, G. F. Bailey, C. E. Bowers, C. D. Wilkinson, C. W. Allen, W. A. Blyckert, W. S. Nechodom, R. E. Tiller, R. H. l-feichle,... 

The investigation process they use does not conform to a detailed protocol or script. The principles are critical, however. According to Mr. Raz, the key principles are ... 

Chandar, N.B., Ganguly, B., 2013. A first principle investigation of aging processes in soman conjugated AChE. Chem. Biol. Interact. 204, 185-190. 

Copper acetate, ferrous acetate, silver acetate [563-63-3] basic aluminum acetate, nickel acetate [373-02-4] cobalt acetate, and other acetate salts have been reported to furnish anhydride when heated. In principle, these acetates could be obtained from low concentration acetic acid. CompHcations of soHds processing and the scarcity of knowledge about these thermolyses make industrial development of this process expensive. In the eady 1930s, Soviet investigators discovered the reaction of dinitrogen tetroxide [10544-72-6] and sodium acetate [127-09-3] to form anhydride ... 

In 1875, a paper by Winkler awakened interest in the contact process, first patented in 1831. Winkler claimed that successfiil conversion of SO2 to SO could only be achieved with stoichiometric, undiluted ratios of SO2 and O2. Although erroneous, this beUef was widely accepted for more than 20 years and was employed by a number of firms. Meanwhile, other German firms expended a tremendous amount of time and money on research. This culminated in 1901 with Knietsch s lecture before the German Chemical Society (3) revealing some of the investigations carried out by the Badische Anilin-iind-Soda-Fahrik. This revealed the abandonment of Winkler s theory and further described principles necessary for successfiil appHcation of the contact process. 

RAIRS is a non-destructive infrared technique with special versatility - it does not require the vacuum conditions essential for electron spectroscopic methods and is, therefore, in principle, applicable to the study of growth processes [4.270]. By use of a polarization modulation technique surfaces in a gas phase can be investigated. Higher surface sensitivity is achieved by modulation of the polarization between s and p. This method can also be used to discriminate between anisotropic near-sur-face absorption and isotropic absorption in the gas phase [4.271]. 

For a complete development of these relationships, see M. Boudart, Kinetics of Chemical Processes. Prentice-Hall, Englewood Cliffs, New Jersey, 1968, pp. 35-46 I. Amdur and G. G. Hammes, Chemical Kinetics, Principles and Selected Topics, McGraw-Hill, New Vbrk, 1966, pp. 43-58 J. W. Moore and R. G. Pearson, Kinetics and Mechanism, John Wiley Sons, New Vbrk, 1981, pp. 159-169 M. M. Kreevoy and D. G. Truhlar, in Investigation ofRates and Mechanisms ofReaction, Techniques of Chemistry, 4th ed., Vol. VT, Part 1, C. F. Bemsscoai, ed., John Wiley Sons, New Ybrk, 1986. 

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