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Pregnancy antiretroviral drugs

A newborn girl born of an HIV-positive mother who took antiretroviral drugs and methadone during pregnancy developed a methadone abstinence syndrome at day 7 (43). She was HIV-negative and was treated symptomatically for 15 days with chlorpromazine. The platelet count was 1049 x 109/1 on day 17 and fell progressively to 290 x 109/1 at 8 weeks. The authors suggested that the thrombocytosis had been secondary to intrauterine methadone exposure. [Pg.581]

Pregnancy and breast-feeding pose especial problems therapy at this time is aimed to minimise toxicity to the fetus while reducing maternal viral load and the catastrophic results of HIV transmission to the neonate. Prevention of maternal-fetal and maternal-infant transmission is the most cost-effective way of using antiretroviral drugs in less developed coimtries. [Pg.259]

Nevirapine is used in combination with at least two other antiretroviral drugs, usually for progressive or advanced HIV infection, although it appears effective also in pregnancy. It penetrates the CSF weU, and undergoes hepatic metabolism (t) 28 h). It is taken once daily, increasing to twice daily if rash is not seen. Rash and hepatitis are the commonest side effects. [Pg.261]

Drugs that may induce metabolism of CHC and reduce efficacy (griseofulvin, antiretroviral History of ectopic pregnancy... [Pg.345]

Itraconazole Topical 1% suspension 1 drop qlh Oral 200 mg PO qd-bid Topical not effective for severe infections, penetrates cornea poorly not commercially available must be compounded Penetrates all eye tissues poorly with oral administration Side effects include hepatotoxicity, gastrointestinal problems, hypokalemia, elevated Uver enzymes, rash, vasculitis, headache, fever, HTN, hypertriglyceridemia Many drug interactions exist including CYP3A4 substrates. Coadministration of itraconazole is contraindicated with multiple antiretrovirals (refer to Table 11-12) Pregnancy category C lactation safety unknown... [Pg.211]

Micafungin Topical 0.1% solution 1 drop ql h while awake Side effects include pulmonary edema, blood dyscrasias, hypercalcemia, hepatotoxicity (rare), gastrointestinal symptoms, headache, fever, chills, anemia, eosinophilia, hypokalemia, liver function test elevations, infusion site reactions. Drug interaction with cyclosporine and additional voriconazole. Pregnancy category C lactation safety unknown. Coadministration of caspofungin is contraindicated with multiple antiretrovirals (refer to Table 11-3) Topical not commercially available... [Pg.212]

Contraception for HIV-positive women is a complex issue. Antiretroviral therapy can lead to drug interactions and modify the efficacy of hormonal contraception. Two unintended pregnancies suggest that ETON implants should be used with caution in patients on efavirenz [61 ]. [Pg.623]


See other pages where Pregnancy antiretroviral drugs is mentioned: [Pg.1267]    [Pg.1900]    [Pg.559]    [Pg.593]    [Pg.593]    [Pg.2272]    [Pg.896]    [Pg.848]    [Pg.1259]    [Pg.382]    [Pg.1834]    [Pg.1079]    [Pg.212]    [Pg.212]    [Pg.1434]    [Pg.2258]    [Pg.847]   
See also in sourсe #XX -- [ Pg.259 ]




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