PRBS

PR 11q22 Two isoforms PRA 769 aa, PRB 933 aa Progesterone AGAACA Uterus, ovary, central nervous system... 

The human PR exists as two functionally distinct isoforms PRA and PRB transcribed from two promoters from a single gene. PRA lacks the N-terminal 164 aa and is a 769 aa protein. PRB functions as a transcriptional activator in most cell and promoter contexts. In contrast, PRA is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of SHR transcriptional activity. Different cofactor interactions were demonstrated for PRA and PRB, probably due to an inhibitory domain within the first 140 aa of PRA, which is masked in PRB. Both PR isoforms however, repress estradiol-induced ER activity when liganded. Several other mRNA isoforms are present in PR-positive tissues such as breast cancer with unknown clinical significance. 

As stated in the previous section, the major reactant feed was chosen as the manipulated variable. In the trial this feed was subjected to a pseudo-random binary sequence (PRBS) signal in an open loop operation of the process. The results of the trial, plotted in Fig. 2, show a strong -- but delayed -- cross-correlation between the manipulated feed rate and the reactor temperature. Using techniques described by Box and Jenkins (2), a transfer function relating the manipulated variable to the control variable of interest can be developed. The general form of this transfer function is... 

Fig. 4.8 Powder X-ray diffraction pattern of pure single-phase Prb-IVand Rietveld refinement.

RB1 Codes for the pRB protein, a master brake of Retinoblastoma, osteosarcoma, and bladder, small cell... 

A permeable reactive barrier (PRB) is defined as an in situ method for remediating contaminated groundwater that combines a passive chemical or biological treatment zone with subsurface fluid flow management. Treatment media may include zero-valent iron, chelators, sorbents, and microbes to address a wide variety of groundwater contaminants, such as chlorinated solvents, other organics,... 

A PRB is a treatment system configuration with treatment zones that can employ any of a number of treatment technologies, such as in situ bioremediation or ISCO. Depending on which treatment technology is employed, the properties of MTBE and other oxygenates as they apply to that specific technology will affect the treatment differently. 

Information relevant to the application of PRBs at sites contaminated with MTBE and other... 

Although no projects in the dataset were identified explicitly to be using PRBs, several projects discussed under other technologies involved these types of components. For example, several bioremediation projects, such as at Port Hueneme, were performed using a PRB configuration. 

No total project cost data were reported for any of the projects in the dataset that employed PRB treatment technology. However, additional information in the literature indicates the application of PRBs for the treatment of other contaminants. A U.S. EPA case study in 2000 showed a range of total costs for 16 PRB projects ranging from USD43,000 to USD1,900,000 with a median total cost of USD680,000.50... 

Phytoremediation or PRBs may be a cost-effective alternative for remediating or containing relatively low-concentration, shallow, and widespread groundwater plumes. 

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