Pramoxine base

Weigh pramoxine base into a separate suitable stainless steel container. 

The condensation of/ -buoxyphenol and 4-(3-chloro-propyl)-morpholine is carried out by refluxing them together in an aqueous medium. On cooling the reaction mixture the pramoxine base is first extracted with benzene, secondly pmified by distillation imder reduced pressure, thirdly dissolved in an appropriate organic solvent, and fourthly converted to the corresponding hydrochloride by means of a stream of hydrogen chloride. 

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