Ion channels potassium

Bliznyuk, A. A. Rendell, A. P., Electronic effects in biomolecular simulations investigations of the KcsA potassium ion channel, J. Phys. Chem. B 2004,108, 13866-13873... 

In regards to necrosis, it is clear that the old adage an ounce of prevention is worth a pound of cure applies. Agents that stabilize ion homeostasis have proved to be effective in preventing necrosis in cell culture studies. For example, drugs that activate plasma membrane potassium ion channels or chloride ion channels can prevent membrane depolarization and so inhibit sodium and calcium ion influx. Agents that prevent large sustained increases in intracellular free calcium levels can also prevent neuronal... 

Potassium, like sodium, is involved in ionic equilibria, and the opening and closing of sodium and potassium ion channels create the electrochemical gradients across cell membranes that transmit nerve impulses and other information and regulate cellular function. 

BaS04 used as contrast agent for radiography and MRI and in bone cements used for the fixation of joint prostheses, Ba inhibits K flux through potassium ion channels Radiation therapy for carcinomas... 

Introduction. Studies on ion channels, potassium ion channels in particular, carried out by Roderick MacKinnon and his research group, resulted in his receiving the 2003 Nobel Prize in chemistry for structural and mechanistic studies of ion channels. Thanks to this contribution and research continuing in the MacKinnon and many other laboratories, it is now possible to... 

Physically, ion channels are tiny pores that stud the surface of all cells. The ion channels are important for, among other things, the function of muscles and the nervous system. These channels allow the passage of potassium, calcium, sodium, and chloride ions. Through a balance of electrical forces and chemical bonds, ion channels are specific for one ion for instance, a potassium ion channel will reject a sodium ion trying to enter its channel. An excellent visualization of the overall process is found at the website http //www. rockefeller.edu/pubinfo/howkion.html. It will be helpful to look at this website before going any further in the discussion. 

The Shaker potassium channel did not yield crystals for the first potassium ion channel X-ray crystallographic structure. Rather, it was the prokaryote bacterium Streptomyces lividans, abbreviated as the KcsA K+ channel, that first produced crystals suitable for crystallography. This structure, published in 1998 by MacKinnon s group in Science magazine, was received with great praise from the scientific community. It was known at that time that the amino acid sequence of KcsA was similar to that of other K channels, including vertebrate and invertebrate voltage-dependent K (Kv) channels (such as the... 

Figure 5.4 Membrane topology for the Shaker potassium ion channel with important residues circled. (Adapted with permission from Figure lA of reference 29. Copyright 2003, with permission from Elsevier.)...

Figure 5.8 Closed and opened views of the potassium ion channel pore according to reference 25. S4 helix of PDB lORQ. Visualized using CambridgeSoft ChemSD Ultra 10.0 with notations in ChemDraw Ultra 10.0. (Printed with permission of CambridgeSoft Corporation.) (See color plate)...

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