MacKinnon. Roderick

MacKinnon, Roderick. (1956-). An American bom in Burlington, MA, who won the Nobel Prize for chemistry in 2003 for his pioneering work discovering channels in cell membranes, in particular for the structural and mechanistic studies of ion channels. He received a B.A. in biochemistry from Brandeis University and an M.D. from Tufts University School of Medicine. MacKinnon is a member of the National Academy of Sciences and was awarded the 1999 Albert Lasker Basic Medical Research Award. 

Introduction. Studies on ion channels, potassium ion channels in particular, carried out by Roderick MacKinnon and his research group, resulted in his receiving the 2003 Nobel Prize in chemistry for structural and mechanistic studies of ion channels. Thanks to this contribution and research continuing in the MacKinnon and many other laboratories, it is now possible to... 

Roderick MacKinnon United States structural and mechanistic studies of ion channels... 

Award of the Nobel prize for Chemistry to Peter Agre and Roderick MacKinnon for their discovery of... 

Just as there are cation channels, there are also trans-membrane channels involved in the transport of biologically important anions such as Cl-. The crystal structure of the CIC chloride channel from Salmonella typhimurium was reported in 2002.3 Along with the determination of the Streptomyces lividans potassium channel structure, this work won a share of the 2003 Nobel prize in chemistry for Roderick MacKinnon (Howard Hughes Medical Institute, New York, USA). Chloride channels catalyse the flow of chloride across cell membranes and play a significant role in functions such as... 

The Nobel Prize in chemistry for 2003 went to Peter Agre for research on aquaporins and to Roderick MacKinnon for research on potassium channels. 

In 1998, Roderick MacKinnon and coworkers determined the structure of a bacterial channel (from Streptomyces lividam) by x-ray crystallogra-... 

A model for voltage gating has been proposed by Roderick MacKinnon and coworkers on the basis of this structure and a range of other experiments (Figure 13.23). In the closed state, the paddles lie in a down" position. On membrane depolarization, the paddles are pulled through the membrane into an up position. In this position, they pull the four sides of the base on the pore apart, increasing access to the selectivity filter and opening the channel. 

Roderick MacKinnon (M.D.) United States United States... 

KcsA channel (Fig. 8-21). The structure of the Tl-P complex is from Gulbis et The drawing is modified from that of Zhou. (C) Ball-and-stick view of the selectivity filter showing positions of four bound K+ ions. Two of the four TVGYG peptide strands of the conduction pore are shown. Courtesy of Roderick MacKinnon. 

Peter Agre, Roderick MacKinnon 1949 WiUiam F. Giauque... 

US biochemist Roderick MacKinnon (1956- ) reveals detailed three-dimensional structure of potassium-ion channel in brain cells. 

Cellular metal ion transport is biologically important because our muscular and nervous systems are regulated by charged species. Cells use membrane channels to extract potassium ions selectively from environments containing both K+ and Na+. Because the K+ ion is /argerthan the Na+ ion, this process cannot be accomplished by simply restricting the channel diameter. Dr. Roderick MacKinnon showed that potassium selectivity arises from a preferential interaction between the potassium cation and the atoms of the protein amino acids composing the channel walls. 

Tube-and-ribbon representation of tbe X-iay stnictnre of a potassinm ion channel by Roderick MacKinnon (Rockefeller University), who received the 2003 Nobel Prize in Chemistry for this work. The key K ion-selectii% portion of the channel is shown wtth side and top-down expansions nsing space-fillii models of the C = 0 groups that line the channel and blue potassium ions. 

Peter Agre, Roderick MacKinnon 1946 James B. Sumner, John H. Northrop, Wendell M. Stanley... 

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