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Postantibiotic effect

For drugs whose killing action is time-dependent, bactericidal activity continues as long as serum concentrations are greater than the MBC. Drug concentrations of time-dependent killing agents that lack a postantibiotic effect should be maintained above the MIC for the entire interval between doses. [Pg.1107]

Persistent suppression of bacterial growth after limited exposure to an antimicrobial agent is known as the postantibiotic effect (PAE). The PAE can be expressed mathematically as follows ... [Pg.1107]

Table 51-4 Antibacterial Agents with In Vitro Postantibiotic Effects 1.5 Hours. ... Table 51-4 Antibacterial Agents with In Vitro Postantibiotic Effects 1.5 Hours. ...
Boswell FJ, Andrews JM, Wise R. Pharmacodynamic properties of BAY 12-8039 on gram-positive and gramnegative organisms as demonstrated by studies of time-kill kinetics and postantibiotic effect. Antimicrob. Agents Chemother., 1997, 41, 1377-1379. [Pg.363]

Table 2.4 PostantIbiotIc effect (PAE) of various antimicrobial agents Postantibiotic effect (h)... Table 2.4 PostantIbiotIc effect (PAE) of various antimicrobial agents Postantibiotic effect (h)...
Craig WA, Gudmundsson S. Postantibiotic effect. In Lorian V, ed. Antibiotics in Laboratory Medicine, 4th ed. Baltimore, Williams Wilkins, 1996 296-329. [Pg.1908]

The ability of bacteriostatic antimicrobial agents to eradicate infections is reliant on host immune function and a postantibiotic effect. Examples include chndamycin, macrolides, and tetracyclines. ... [Pg.1915]

Xue IB, Davey PG, Phillips G. Variation in postantibiotic effect of clindamycin against clinical isolates of Staphylococcus aureus and implications for dosing of patients with osteomyelitis. Antimicrob Agents Chemother 1996 40 1403-1407. [Pg.2129]

Amikacin is eliminated anteriorly and has a half-life similar to that of vancomycin at 25.5 hours in the normal phakic eye (49). Inflammation decreases the half-life and removal of the lens significantly reduces the half-life to 14.3 hours in the rabbit although the effect is not quite as marked as the changes for vancomycin. Amikacin is a concentration-dependent antibiotic with a postantibiotic effect that is, there is prolonged activity even after its concentrations have fallen below therapeutic levels. [Pg.92]

Antibacterial effects depend mainly on peak drug level (rather than time) and continue with blood levels < MIC—a postantibiotic effect (PAE). [Pg.493]

These agents have a significant postantibiotic effect. [Pg.269]

See other pages where Postantibiotic effect is mentioned: [Pg.412]    [Pg.520]    [Pg.538]    [Pg.539]    [Pg.541]    [Pg.1021]    [Pg.1022]    [Pg.1027]    [Pg.1106]    [Pg.1107]    [Pg.1067]    [Pg.1177]    [Pg.1179]    [Pg.1179]    [Pg.282]    [Pg.134]    [Pg.120]    [Pg.20]    [Pg.323]    [Pg.323]    [Pg.64]    [Pg.1901]    [Pg.1902]    [Pg.1902]    [Pg.1906]    [Pg.1914]    [Pg.2062]    [Pg.2138]    [Pg.175]    [Pg.269]    [Pg.754]    [Pg.389]    [Pg.391]   
See also in sourсe #XX -- [ Pg.20 , Pg.29 ]

See also in sourсe #XX -- [ Pg.1902 , Pg.1902 ]

See also in sourсe #XX -- [ Pg.449 ]

See also in sourсe #XX -- [ Pg.1034 ]

See also in sourсe #XX -- [ Pg.127 , Pg.129 ]



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