Position emission tomography

A fourth approach to evaluating the intactness of dopamine and/or serotonin neurons in human subjects who have taken one of the amphetamine analogs might be to use a probe for labeling a constituent of those neurons in position emission tomography scanning studies. A label for the serotonin or dopamine uptake carrier, or a label for tryptophan hydroxylase or tyrosine... 

Novel agonist 5HTia receptor position emission tomography (PET) ligands derived form l,2,4-triazine-3,5-dione 19 have been synthesized and evaluated in vivo <06JMC125 06BMCL2101>. 

The other enzyme involved in the synthesis of 5-HT, aromatic L-amino acid decarboxylase (AADC) (EC 4.1.1.28), is a soluble pyridoxal-5 -phosphate-dependent enzyme, which converts 5-HTP to 5-HT (Fig. 13-5). It has been demonstrated that administration of pyridoxine increases the rate of synthesis of 5-HT in monkey brain, as revealed using position emission tomography (this technique is discussed in Ch. 58). This presumably reflects a regulatory effect of pyridoxine on AADC activity and raises the interesting issue of the use of pyridoxine supplementation in situations associated with 5-HT deficiency. 

First European installation of Biograph, a combined position emission tomography (PET) and computed tomography (CT) system... 

OCS Oncology care system PET Position emission tomography RV Vacuum technology SP Special systems SW Software workstations US Ultrasound... 

Eriedland, R.P., et al. Regional Cerebral Metabolic Alterations in Dementia of the Alzheimer Type Position Emission Tomography, J. Compul. Assist. I omogr., 590 (July 1983),... 

However Suehiro and coworkers [81] showed that C-McN 5652 is probably a very useful tool for in vivo mapping of 5-HT-uptake sites in the central fiervous system by position emission tomography (PET) and studying changes in these site brought about by pharmacological intervention or otherwise. 

Schuster DP. Position emission tomography theory and its application to the smdy of lung disease. Am Rev Resp Med 1989 139 818-840. 

Fig. 22.1 Position emission tomography image of Alzheimer disease and normeil brain (coronal and transverse sections through the hippocampus) (See also Color Insert)...

Ricci, P., Karis, J., Heiserman, J., Fram, E., Bice, A., Drayer, B. Differentiating recurrent tumor from radiation necrosis time for re-evaluation of position emission tomography Am. J. Nemoradiol. 19,407-413 (1998)... 

In, and Lu nucleotide metabolism studies with P-and P-labeled adenosine triphosphate (ATP) or guano-sine triphosphate (GTP) " C-UDPGA glucuronidation assay quality control (QC) of Lu- and Y-DOTA-TOC silica gel TLC for analysis of position emission tomography (PET) radiochemicals QC of Tc and radiochemical purity of ZevaUn. 

Seltzer MA, Barbaric Z, Belldegrun A, Naitoh J, Dorey F, Phelps ME, Gambhir SS, Hoh CK. Comparison of helical computerized tomography, position emission tomography and monoclonal antibody scans for evaluation of lymph node metastases in patients with prostate specific antigen relapse after treatment for localized prostate cancer. J Urol 1999 162 1322-1328. 

Anderson GS, Brinkmann F, Soulen MC, et al (2003) FDG position emission tomography in the surveillance of hepatic tumors treated with radiofrequency ablation. Clin Nucl Med 28 192-197... 

Although many theoretical advantages of MRT have been reviewed, a perceived disadvantage of the technique is that only small quantities of material can be synthesized in such reactors. Until recently, this meant that most published literature had focused on the synthesis of small quantities of material and/or niche applications such as position emission tomography radiosynthesis. 

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