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GPCR structure

Key Words Chemokines receptors GPCR structure inflammation immunology biochemistry. [Pg.31]

Visiers, I., Ballesteros, J. A., and Weinstein, H. (2002) Computational methods for the construction and analysis of three dimensional representations of GPCR structures and mechanisms. Methods Enzymol 343, 329-371. [Pg.229]

With time, the relevance of in vivo mutations with respect to structural in vitro data will provide a detailed population model of the receptors of family A, which share structnral similarity to rhodopsin. Comparison of these data with the family B GPCRs, the glncagon-like receptors (255,256), and the family C receptors, such as the CASR, may provide the detail necessary to model how GPCR structure and function are altered by common genetic variants. [Pg.168]

Numerous insightful reviews detail the use of the rhodopsin crystal structure as a model building template for other class A GPCRs (Archer et al., 2003 Ballesteros et al., 2001 Becker et al., 2003 FUipek et al, 2003). Modeling studies of GPCR structure have been advanced to such an extent that ab initio structure prediction methods using the minimum possible experimental structural information are underway (Vaidehi et al., 2002). [Pg.408]

Congreve M, Marshall F (2010) The impact of GPCR structures on pharmacology and structure-based thug design. Br J Pharmacol 159 986-996... [Pg.218]


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See also in sourсe #XX -- [ Pg.391 ]




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