Polyunsaturated fatty acids biochemistry

Bell, M.V., Henderson, R.J. and Sargent, J.R. (1986). The role of polyunsaturated fatty acids in fish. Comparative Biochemistry and Physiology 83B, 711-719. 

Ackman, R.G. and Cunnane, S.C. (1992) Long-chain polyunsaturated fatty acids sources, biochemistry, and nutritional/clinical applications. Adv. Appl. Lipid Res., 1, 161-215. 

Martin RE, De Turco EBR, Bazan N. Developmental maturation of hepatic n-3 polyunsaturated fatty acid metabolism supply of docosahexaenoic acid to retina and brain. J Nutral Biochemistry 1994 5 151-160. 

Jump, D. B. The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem 277 (2002) 8755-8758. 

G. L. Russo (2009) Dietary n-6 and n-3 polyunsaturated fatty acids From biochemistry to clinical implications in cardiovascular prevention. Biochem Pharmacol, 77, 937-946. 

Martinez-Lorenzo, M. J., Marzo, I., Naval, J. et al. (1994) Self-staining of polyunsaturated fatty acids in argentation thin-layer chromatography. Analytical Biochemistry, 220 (1), 210-12. 

His work has been done in the Faculty of Ciencias Exactas at Buenos Aires University. I personally had the pleasure of working in his laboratory and there began in 1946 several studies on lipids. First we studied fish lipids and waxes. Then we started a series of research projects on polyunsaturated fatty acid biosynthesis in different species of the animal kingdom as well as on the lipid metabolism and the effect of diabetes on tumor cells. Our group, the oldest in continuous research in lipid biochemistry, developed in the Catedra de Bioquimica of the Institute de Fisiologia of the Faculty of Medicine of La Plata University. To this group belong... 

Bell, MV and Sargent, JR (1987) Effects of the fatty acid composition of phosphatidylserine and diacylglycerol on the in vitro activity of protein kinase C from rat spleen influences of (n-3) and (n-6) polyunsaturated fatty acids. Comparative Biochemistry and Physiology, 86B, 227-232. 

Metabolism of polyunsaturated fatty acids. VI. International Congress of Biochemistry, New York 1964. 

Innis, S.M. Perinatal biochemistry and physiology of long chain polyunsaturated fatty acids. J. Pediatr. 2003, 143, S1-S8. 

Lusso, G.L. Dietary n-6 and n-3 polyunsaturated fatty acids From biochemistry to clinical impheations in cardiovascular prevention. Biochem. Pharmacol. 2009,77, 937-946. Min, D.B. Calhson, A.L. Lee, H.O. Singlet oxygen oxidation for 2-pentylfuran and 2-pente-nylfuran formation in soybean oil. J. Food Sci. 2003, 68,1175-1178. 

Bellou, S., Moustogianni, A., Makri, A., Aggehs, G., 2012. Lipids containing polyunsaturated fatty acids synthesized by Zygomycetes grown on glycerol. Applied Biochemistry and Biotechnology 166, 146—158. 

Figure 7. Relationship of oxidation and degree of polyunsaturation. Polyunsaturation is measured as the methylene bridge index (MBI), which is a more precise measure of extent of unsaturation and oxidizability than the double bond index. It is the mean number of 6is-allylic methylene bridge positions per fatty acid (or fatty acyl chain) in a lipid ensemble. The rate of lipid radical formation measures formation of an oxidative product, while O2 consumption (% O2 lost per sec) is a measure of utilization of a reactant. (Drawn using our data abstracted from Wagner, B.A., Buettner, G.R., and Bums, C.P. 1994, Biochemistry 33 4449-4453).

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