Polysaccharides Salmonella typhi

It is prepared from Vi capsular polysaccharide of Salmonella typhi. Immunity develops 7 to 15 days after injection and protection lasts for three years. 

Bacterial Tuberculosis (BCG) Salmonella typhi Ty21a Salmonella typhi Cholera Vi capsular polysaccharide... 

G. Chatfield, S. Characterization of defined ompR mutants of Salmonella typhi ompR is involved in the regulation of Vi polysaccharide expression. Infect. Immun., 61, 3984-3993 (1994)... 

The method has also been applied to acetylated polysaccharides. Thus, whereas the D-mannopyranose residue in the acetylated lipo-polysaccharide from Salmonella typhi was found to be inert, that in Salmonella Strasbourg was oxidized, demonstrating that the former is a-D-linked and the latter /3-D-linked.154 The D-mannose residues in the acetylated lipopolysaccharide from Klebsiella O-group 3 were found resistant to oxidation, and are consequently a-D-linked."... 

Promegestone Propfol injection Propoxur + flumethrin Purified chick embryo cell tissue Purified vicapsular polysaccharide of salmonella typhi Rabbit Antihuman thymocyte immunoglobulin intravenous Rabies vaccine inactivated (Vero-Cell)... 

Vi capsular polysaccharide vaccine and vaccines based on auxotrophic mutants of Vi-positive and Vi-negative Salmonella typhi (SED-11, 687) (SEDA-12, 278) (SEDA-13, 284) (SEDA-14, 281). 

Glycoconjugate vaccines from other capsular polysaccharides are in preclinical or clinical evaluation steps for Group B Streptococcus, Salmonella typhi. Shigellosis, Cholera, and Staphylococcus aureus. 

The quantity of capsular polysaccharide is apparently of importance in a variety of pathogens. Klebsiella pneumoniae. Salmonella typhi, 5. typhi-murium, E. coli. Streptococcus pneumoniae and Staphylococcus aureus have all been reported to show a relationship between the amount of capsular material and virulence, resistance to phagocytosis, or resistance to humoral host defences. It has been suggested in the case of E. coli that the amount of K-antigen, as measured by its ability to coat red blood cells and inhibit their aggregation by haemagglutinating antiserum, is the most important factor determining resistance to the complement-mediated bactericidal activity of serum. Other studies have found evidence that the type of capsular polysaccharide may be more important. 

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